Disease relevance of ASF1A

• In adenocarcinomas, the incidence of HB-EGF expression significantly decreased as compared to adenomas with moderate or severe dysplasia (p < 0.0001) and CIA (p = 0.0005), with only 27.5% of the cases being classified as positive [1].
• Periodic fluctuation of leukocytes, platelets and reticulocytes in a case of chronic myelocytic leukemia: the relation between leukocyte counts, CFU-C colony formation, CSA and CIA [2].

High impact information on ASF1A

• Biogenesis of cytosolic and nuclear Fe/S proteins is facilitated by the cytosolic iron-sulfur protein assembly (CIA) apparatus [3].
• Here we show the identification and characterization of human CIA/hASF1 (identified previously as a histone chaperone) as an interactor of two tandem bromodomain modules of human (h)TAF(II)250/CCG1, the largest subunit of TFIID [4].
• The factor hCIA interacts with hCCG1 and functions as a histone chaperone in mammalian cells; its homologue in yeast is Asf1p/Cia1p [5].
• Defects in the mitochondrial ISC assembly and export systems, but not in the CIA machinery have a strong impact on cellular iron uptake and intracellular iron distribution showing that mitochondria are crucial for both cellular Fe/S protein assembly and iron homeostasis [6].
• There are numerous other useful negotiating tools, including Escalation, the Limit, the Krunch, Call for Higher Authority, CIA, Intimidation, Churning, Phoney Offers-unfortunately, too many to detail in this short chapter [7].

References