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Gene Review

asf1  -  anti-silencing factor 1

Drosophila melanogaster

Synonyms: ASF1, Anti-silencing function protein 1, Asf1, CG9383, Dmel\CG9383, ...
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Disease relevance of asf1

  • ASF-1 produced in E. coli can activate splicing in vitro and switch 5' splice-site utilization, establishing that the recombinant protein is sufficient to supply these activities [1].

High impact information on asf1

  • Use of the upstream site results in a second mRNA (ASF-2) in which translation of the downstream exon occurs extensively in an alternative reading frame distinct from ASF-1 [1].
  • ASF-1 consists of 248 amino acid residues, including an 80 residue RNA-binding domain at its N-terminus and a 50 residue C-terminal region that is 80% serine plus arginine [1].
  • Genetic analyses in Saccharomyces cerevisiae demonstrate that ASF1 is essential for normal cell cycle progression, and suggest that RCAF mediates chromatin assembly after DNA replication and the repair of double-strand DNA damage in vivo [2].
  • In mammals, their activity peaks during S phase, when they phosphorylate the antisilencing function protein 1 (ASF1), a histone chaperone involved in replication-dependent chromatin assembly [3].
  • Here, we show that Drosophila ASF1 is also a phosphorylation target of TLK, and that the two components cooperate to control chromatin replication in vivo [3].

Biological context of asf1


Associations of asf1 with chemical compounds


Other interactions of asf1

  • The analysis of native and recombinant dCAF-1 revealed an interaction between dCAF-1 and the Drosophila anti-silencing function 1 (dASF1) component of replication-coupling assembly factor (RCAF) [4].
  • The assembly and disassembly of chromatin structures from histone proteins and DNA are mediated by histone chaperones, including the histone H3/H4 chaperone anti-silencing function 1 (ASF1) [5].


  1. Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. Ge, H., Zuo, P., Manley, J.L. Cell (1991) [Pubmed]
  2. The RCAF complex mediates chromatin assembly during DNA replication and repair. Tyler, J.K., Adams, C.R., Chen, S.R., Kobayashi, R., Kamakaka, R.T., Kadonaga, J.T. Nature (1999) [Pubmed]
  3. Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions. Carrera, P., Moshkin, Y.M., Gronke, S., Sillje, H.H., Nigg, E.A., Jackle, H., Karch, F. Genes Dev. (2003) [Pubmed]
  4. Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors. Tyler, J.K., Collins, K.A., Prasad-Sinha, J., Amiott, E., Bulger, M., Harte, P.J., Kobayashi, R., Kadonaga, J.T. Mol. Cell. Biol. (2001) [Pubmed]
  5. The histone chaperone ASF1 localizes to active DNA replication forks to mediate efficient DNA replication. Schulz, L.L., Tyler, J.K. FASEB J. (2006) [Pubmed]
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