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Gene Review:

ABI3BP - ABI family, member 3 (NESH) binding protein

Homo sapiens

Synonyms: ABI gene family member 3-binding protein, DKFZP586L2024, NESHBP, Nesh-binding protein, NeshBP, ...

Terauchi, K. et al., Uekawa, N. et al., Guimarães, G.S. et al.

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Disease relevance of ABI3BP

Cancer-associated loss of TARSH gene expression in human primary lung cancer [1].
TARSH is a presumptive signal transduction molecule interacting with NESH, which is implicated to have some roles in lung cancer metastasis [1].

High impact information on ABI3BP

PTPN18, ABI3BP, and PFDN5 revealed a statistically significant differential splicing profile [2].
PURPOSE: We have previously identified mouse Tarsh as one of the cellular senescence-related genes and showed the loss of expression of TARSH mRNA in four human lung cancer cell lines [1].
Thus, TARSH presumably represents a trigger gene for evoking cellular senescence, which has also been suggested to be involved in the prevention of tumorigenesis [3].

Biological context of ABI3BP

Expression of TARSH gene in MEFs senescence and its potential implication in human lung cancer [3].

Anatomical context of ABI3BP

We also show that mTARSH mRNA predominantly expressed in lung and that conspicuous expression of TARSH was drastically declined in all several lung cancer cell lines we tested [3].

Analytical, diagnostic and therapeutic context of ABI3BP

Northern blotting was carried out using TARSH cDNA probes [1].

References

Cancer-associated loss of TARSH gene expression in human primary lung cancer. Terauchi, K., Shimada, J., Uekawa, N., Yaoi, T., Maruyama, M., Fushiki, S. J. Cancer Res. Clin. Oncol. (2006) [Pubmed]
Identification of candidates for tumor-specific alternative splicing in the thyroid. Guimarães, G.S., Latini, F.R., Camacho, C.P., Maciel, R.M., Dias-Neto, E., Cerutti, J.M. Genes Chromosomes Cancer (2006) [Pubmed]
Expression of TARSH gene in MEFs senescence and its potential implication in human lung cancer. Uekawa, N., Terauchi, K., Nishikimi, A., Shimada, J., Maruyama, M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]

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