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Gene Review

NSL1  -  NSL1, MIS12 kinetochore complex component

Homo sapiens

Synonyms: C1orf48, DC31, DC8, DKFZP566O1646, Kinetochore-associated protein NSL1 homolog, ...
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High impact information on NSL1

  • Four other human proteins of unknown function (c20orf172, DC8, PMF1 and KIAA1570) correspond to yeast Mis12-Mtw1 complex components and are shown to be required for chromosome segregation in HeLa cells using RNA interference (RNAi) [1].
  • Double HP1 RNAi abolishes kinetochore localization of hMis12 and DC8 [1].
  • Factors involved in the formation of the C3 and C4 complexes could be competed with sequences upstream of DC 8, a gene that is coordinately expressed with DC 59 during embryo development [2].
  • DNase I footprinting analysis revealed that nuclear extracts from embryos bound to four AT-rich sequences, and the protected motifs within fragment V were located in the highly homologous upstream regions of DC 59 and DC 8 genes [2].
  • However, DC8 cannot be induced by ABA in adult tissues [3].

Biological context of NSL1

  • Molecular analysis of the DNA from several haploid and diploid carrots showed that the mRNA was encoded by a single copy gene, named DC 8 [4].

Anatomical context of NSL1

  • The region of the DC8 promoter from -170 to -51 contained ABA-responsive sequences that required a 5' upstream region for high levels of expression in embryogenic callus protoplasts [3].

Associations of NSL1 with chemical compounds

  • This agent was found to produce partial inhibition of formation of phosphatidic acid in human platelets challenged with thrombin, DC8 or OAG [5].

Analytical, diagnostic and therapeutic context of NSL1

  • Sequence analysis of the pMA1949 clone shows it to be a 991 bp partial cDNA encoding a polypeptide of 317 amino acids with homology to two group 3 LEA proteins, carrot (DC8) and a soybean protein encoded by pGmPM2 cDNA [6].
  • Combined CTLA4Ig and anti-CD4/DC8 monoclonal antibody treatment prolongs survival of rat-to-mouse heterotopic cardiac xenografts [7].


  1. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Obuse, C., Iwasaki, O., Kiyomitsu, T., Goshima, G., Toyoda, Y., Yanagida, M. Nat. Cell Biol. (2004) [Pubmed]
  2. Interaction of nuclear factors with upstream sequences of a lipid body membrane protein gene from carrot. Hatzopoulos, P., Franz, G., Choy, L., Sung, R.Z. Plant Cell (1990) [Pubmed]
  3. Transcriptional regulation of a seed-specific carrot gene, DC8. Goupil, P., Hatzopoulos, P., Franz, G., Hempel, F.D., You, R., Sung, Z.R. Plant Mol. Biol. (1992) [Pubmed]
  4. Molecular and genetic analysis of an embryonic gene, DC 8, from Daucus carota L. Franz, G., Hatzopoulos, P., Jones, T.J., Krauss, M., Sung, Z.R. Mol. Gen. Genet. (1989) [Pubmed]
  5. The diacylglycerol kinase inhibitor, R59949, potentiates secretion but not increased phosphorylation of a 47 kDalton protein in human platelets. Rodríguez-Liñares, B., Walker, T., Watson, S. Biochem. Pharmacol. (1991) [Pubmed]
  6. Unusual sequence of group 3 LEA (II) mRNA inducible by dehydration stress in wheat. Curry, J., Walker-Simmons, M.K. Plant Mol. Biol. (1993) [Pubmed]
  7. Combined CTLA4Ig and anti-CD4/DC8 monoclonal antibody treatment prolongs survival of rat-to-mouse heterotopic cardiac xenografts. Rehman, A., Tu, Y., Flye, M.W. Transplant. Proc. (1996) [Pubmed]
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