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Gene Review

RPAP1  -  RNA polymerase II associated protein 1

Homo sapiens

Synonyms: DKFZP727M111, FLJ12732, KIAA1403, MGC858, RNA polymerase II-associated protein 1
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Disease relevance of RPAP1


High impact information on RPAP1


Biological context of RPAP1

  • The concentration of ATP required for the phosphorylation of RNA polymerase II associated with the preinitiation complex is two to three orders of magnitude lower than that required for the conversion of RNA polymerase IIA to IIO free in solution [6].
  • In order to understand how glycosylation may modulate or regulate antibody binding of mucin protein core epitopes, we have analyzed the antibody C595 (epitope RPAP) for its structure, stability, and its binding to a series of synthetic peptides and glycopeptides by a number of spectroscopic methods [7].
  • Epitope mapping experiments using overlapping octapeptides in the repeat unit of the PEM identified in the RPAP (Arg-Pro-Ala-Pro) sequence the binding site of the 436 antigen.(ABSTRACT TRUNCATED AT 250 WORDS)[8]


  1. Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. Yang, L., Li, N., Wang, C., Yu, Y., Yuan, L., Zhang, M., Cao, X. J. Biol. Chem. (2004) [Pubmed]
  2. Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator. Malik, S., Baek, H.J., Wu, W., Roeder, R.G. Mol. Cell. Biol. (2005) [Pubmed]
  3. RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits. Jeronimo, C., Langelier, M.F., Zeghouf, M., Cojocaru, M., Bergeron, D., Baali, D., Forget, D., Mnaimneh, S., Davierwala, A.P., Pootoolal, J., Chandy, M., Canadien, V., Beattie, B.K., Richards, D.P., Workman, J.L., Hughes, T.R., Greenblatt, J., Coulombe, B. Mol. Cell. Biol. (2004) [Pubmed]
  4. Topological localization of the human transcription factors IIA, IIB, TATA box-binding protein, and RNA polymerase II-associated protein 30 on a class II promoter. Coulombe, B., Li, J., Greenblatt, J. J. Biol. Chem. (1994) [Pubmed]
  5. Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression. Woodard, G.E., Lin, L., Zhang, J.H., Agarwal, S.K., Marx, S.J., Simonds, W.F. Oncogene (2005) [Pubmed]
  6. Phosphorylation of RNA polymerase IIA occurs subsequent to interaction with the promoter and before the initiation of transcription. Laybourn, P.J., Dahmus, M.E. J. Biol. Chem. (1990) [Pubmed]
  7. Structure/activity studies of the anti-MUC1 monoclonal antibody C595 and synthetic MUC1 mucin-core-related peptides and glycopeptides. Spencer, D.I., Missailidis, S., Denton, G., Murray, A., Brady, K., Matteis, C.I., Searle, M.S., Tendler, S.J., Price, M.R. Biospectroscopy. (1999) [Pubmed]
  8. Characterization of monoclonal antibody 436 recognizing the Arg-Pro-Ala-Pro sequence of the polymorphic epithelial mucin (PEM) protein core in breast carcinoma cells. Nuti, M., Turchi, V., Rughetti, A., Viacava, P., Masci, A.M., Castagna, M., Frati, L. Int. J. Biol. Markers (1992) [Pubmed]
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