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Gene Review

BUNVsSgp1  -  N protein

Bunyamwera virus

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Disease relevance of BUNVsSgp1

  • Thus, phylogenetic analysis of the AKA virus N protein gene gives a greater insight into bunyavirus evolution [1].
  • Earlier we have shown that Tula hantavirus N protein oligomerization is dependent on the C-terminal domains [2].
  • The SSH/LAC/SSH recombinant appears, from polypeptide analysis, to have the SSH type of nucleocapsid protein (N), whereas the SSH/LAC/LAC recombinant has the LAC nucleocapsid protein, suggesting that the viral S RNA codes for the N protein [3].
  • The recombinants had the G protein of the Maguari virus parent and the N protein of the Bunyamwera virus parent [4].
  • Instead the parental origin of the S RNA subunit was inferred from the electrophoretic mobility of the virion N protein [5].

High impact information on BUNVsSgp1

  • Group I appeared to correspond to the genome subunit coding for the N protein, and group II corresponded to the G1/G2 determinant [6].
  • All N protein ORFs were 708 nucleotides in length and encoded a 235 amino-acid gene product [7].
  • An additional ORF of 150 nucleotides coding for a possible 5.9-kDa protein is present in the +1 reading frame, 3' to the N protein ORF on vcRNA [8].
  • In cells infected with ts12 , accumulation of G1 and G2, but not N protein, was observed in the Golgi complex at 39 degrees C. The N protein was found evenly scattered in the cytoplasm, suggesting lack of interaction between the G1/G2 and N proteins [9].
  • With ts6 and 11, G1 and G2 appeared to accumulate and aggregate in the endoplasmic reticulum (ER) at 39 degrees C. The location of the N protein coincided with that of the aggregated glycoproteins, suggesting that the N protein interacted with G1/G2 already in the ER [9].

Chemical compound and disease context of BUNVsSgp1

  • Analysis of the major Tacaribe virus-specified product by two-dimensional polyacrylamide gel electrophoresis indicated that it had an isoelectric point similar to that of the Tacaribe nucleocapsid polypeptide N; however, the in vitro product had an approximate mol. wt. of 73 000, compared to a mol. wt. of 68 000 for the N protein [10].

Biological context of BUNVsSgp1

  • All N protein ORFs were 708 nucleotides in length and encoded a putative 235 amino acid gene product [11].

Analytical, diagnostic and therapeutic context of BUNVsSgp1


  1. Sequence determination and phylogenetic analysis of the Akabane bunyavirus S RNA genome segment. Akashi, H., Kaku, Y., Kong, X.G., Pang, H. J. Gen. Virol. (1997) [Pubmed]
  2. Oligomerization of Hantavirus N protein: C-terminal alpha-helices interact to form a shared hydrophobic space. Kaukinen, P., Kumar, V., Tulimäki, K., Engelhardt, P., Vaheri, A., Plyusnin, A. J. Virol. (2004) [Pubmed]
  3. Formation of recombinants between snowshoe hare and La Crosse bunyaviruses. Gentsch, J., Wynne, L.R., Clewley, J.P., Shope, R.E., Bishop, D.H. J. Virol. (1977) [Pubmed]
  4. Mutant identifying a third recombination group in a bunyavirus. Pringle, C.R., Iroegbu, C.U. J. Virol. (1982) [Pubmed]
  5. Genome subunit reassortment among Bunyaviruses analysed by dot hybridization using molecularly cloned complementary DNA probes. Pringle, C.R., Lees, J.F., Clark, W., Elliott, R.M. Virology (1984) [Pubmed]
  6. Genetic interactions among viruses of the Bunyamwera complex. Iroegbu, C.U., Pringle, C.R. J. Virol. (1981) [Pubmed]
  7. The S RNA genomic sequences of Inkoo, San Angelo, Serra do Navio, South River and Tahyna bunyaviruses. Huang, C., Shope, R.E., Spargo, B., Campbell, W.P. J. Gen. Virol. (1996) [Pubmed]
  8. Coding strategy of the S RNA segment of Dugbe virus (Nairovirus; Bunyaviridae). Ward, V.K., Marriott, A.C., el-Ghorr, A.A., Nuttall, P.A. Virology (1990) [Pubmed]
  9. Characterization of two recombination-complementation groups of Uukuniemi virus temperature-sensitive mutants. Gahmberg, N. J. Gen. Virol. (1984) [Pubmed]
  10. Synthesis of Tacaribe virus polypeptides in an in vitro coupled transcription and translation system. Boersma, D.P., Compans, R.W. Virus Res. (1985) [Pubmed]
  11. Determination and comparative analysis of the small RNA genomic sequences of California encephalitis, Jamestown Canyon, Jerry Slough, Melao, Keystone and Trivittatus viruses (Bunyaviridae, genus Bunyavirus, California serogroup). Bowen, M.D., Jackson, A.O., Bruns, T.D., Hacker, D.L., Hardy, J.L. J. Gen. Virol. (1995) [Pubmed]
  12. Homotypic interaction of Bunyamwera virus nucleocapsid protein. Leonard, V.H., Kohl, A., Osborne, J.C., McLees, A., Elliott, R.M. J. Virol. (2005) [Pubmed]
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