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Gene Review

NS  -  nonstructural protein

Uukuniemi virus

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Disease relevance of NS


High impact information on NS

  • When such cells were either superinfected with Uukuniemi virus or cotransfected with expression plasmids encoding the L (RNA polymerase), N (nucleoprotein), and NSs (nonstructural protein) viral proteins, strong CAT activity or GFP expression was observed [6].
  • All pathogenic RVFV strains direct the synthesis of a nonstructural phosphoprotein (NSs) that is encoded by the smallest (S) segment of the tripartite genome and has an undefined accessory function [7].
  • A method for quantifying the small RNA segment by a real-time detection reverse transcription (RT)-PCR using TaqMan technology and targeting the nonstructural protein-coding region was developed, and primers and a probe were designed [8].


  1. Uukuniemi virus S RNA segment: ambisense coding strategy, packaging of complementary strands into virions, and homology to members of the genus Phlebovirus. Simons, J.F., Hellman, U., Pettersson, R.F. J. Virol. (1990) [Pubmed]
  2. The S segment of rift valley fever phlebovirus (Bunyaviridae) carries determinants for attenuation and virulence in mice. Vialat, P., Billecocq, A., Kohl, A., Bouloy, M. J. Virol. (2000) [Pubmed]
  3. Association of the nonstructural protein NSs of Uukuniemi virus with the 40S ribosomal subunit. Simons, J.F., Persson, R., Pettersson, R.F. J. Virol. (1992) [Pubmed]
  4. The carboxy-terminal acidic domain of Rift Valley Fever virus NSs protein is essential for the formation of filamentous structures but not for the nuclear localization of the protein. Yadani, F.Z., Kohl, A., Préhaud, C., Billecocq, A., Bouloy, M. J. Virol. (1999) [Pubmed]
  5. The Rift Valley fever virus nonstructural protein NSs is phosphorylated at serine residues located in casein kinase II consensus motifs in the carboxy-terminus. Kohl, A., di Bartolo, V., Bouloy, M. Virology (1999) [Pubmed]
  6. Reverse genetics system for Uukuniemi virus (Bunyaviridae): RNA polymerase I-catalyzed expression of chimeric viral RNAs. Flick, R., Pettersson, R.F. J. Virol. (2001) [Pubmed]
  7. Genetic evidence for an interferon-antagonistic function of rift valley fever virus nonstructural protein NSs. Bouloy, M., Janzen, C., Vialat, P., Khun, H., Pavlovic, J., Huerre, M., Haller, O. J. Virol. (2001) [Pubmed]
  8. Quantitative real-time PCR detection of Rift Valley fever virus and its application to evaluation of antiviral compounds. Garcia, S., Crance, J.M., Billecocq, A., Peinnequin, A., Jouan, A., Bouloy, M., Garin, D. J. Clin. Microbiol. (2001) [Pubmed]
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