Gene Review:
Sptlc1 - serine palmitoyltransferase, long chain...
Mus musculus
Synonyms:
AW552086, C77762, E030036H05, LCB 1, Lcb1, ...
- Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Hanada, K. Biochim. Biophys. Acta (2003)
- Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model. Umehara, T., Sudoh, M., Yasui, F., Matsuda, C., Hayashi, Y., Chayama, K., Kohara, M. Biochem. Biophys. Res. Commun. (2006)
- A novel role for sphingolipid intermediates in activation-induced cell death in T cells. Solomon, J.C., Sharma, K., Wei, L.X., Fujita, T., Shi, Y.F. Cell Death Differ. (2003)
- Production of ceramides causes apoptosis during early neural differentiation in vitro. Herget, T., Esdar, C., Oehrlein, S.A., Heinrich, M., Schütze, S., Maelicke, A., van Echten-Deckert, G. J. Biol. Chem. (2000)
- cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. van Echten-Deckert, G., Zschoche, A., Bär, T., Schmidt, R.R., Raths, A., Heinemann, T., Sandhoff, K. J. Biol. Chem. (1997)
- Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2. Nakamura, S., Kozutsumi, Y., Sun, Y., Miyake, Y., Fujita, T., Kawasaki, T. J. Biol. Chem. (1996)
- Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. Mandon, E.C., Ehses, I., Rother, J., van Echten, G., Sandhoff, K. J. Biol. Chem. (1992)
- Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Dobrzyn, A., Dobrzyn, P., Lee, S.H., Miyazaki, M., Cohen, P., Asilmaz, E., Hardie, D.G., Friedman, J.M., Ntambi, J.M. Am. J. Physiol. Endocrinol. Metab. (2005)
- Sphingolipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid bases. Mandon, E.C., van Echten, G., Birk, R., Schmidt, R.R., Sandhoff, K. Eur. J. Biochem. (1991)
- Disruption of sphingolipid homeostasis by myriocin, a mycotoxin, reduces thymic and splenic T-lymphocyte populations. Johnson, V.J., He, Q., Osuchowski, M.F., Sharma, R.P. Toxicology (2004)
- Cycloserine and threo-dihydrosphingosine inhibit TNF-alpha-induced cytotoxicity: evidence for the importance of de novo ceramide synthesis in TNF-alpha signaling. Meyer, S.G., de Groot, H. Biochim. Biophys. Acta (2003)
- Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. Merrill, A.H., van Echten, G., Wang, E., Sandhoff, K. J. Biol. Chem. (1993)
- Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in primary cultured cerebellar neurons. Triola, G., Fabrias, G., Dragusin, M., Niederhausen, L., Broere, R., Llebaria, A., van Echten-Deckert, G. Mol. Pharmacol. (2004)
- Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway. Merrill, A.H., Wang, E., Mullins, R.E. Biochemistry (1988)
- Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice. Park, T.S., Panek, R.L., Rekhter, M.D., Mueller, S.B., Rosebury, W.S., Robertson, A., Hanselman, J.C., Kindt, E., Homan, R., Karathanasis, S.K. Atherosclerosis (2006)
- Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes induction of c-myc in mouse liver. He, Q., Johnson, V.J., Osuchowski, M.F., Sharma, R.P. Mycopathologia (2004)
- Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition. He, Q., Riley, R.T., Sharma, R.P. Toxicol. Appl. Pharmacol. (2001)