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Gene Review

Sptlc1  -  serine palmitoyltransferase, long chain...

Mus musculus

Synonyms: AW552086, C77762, E030036H05, LCB 1, Lcb1, ...
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Disease relevance of Sptlc1


High impact information on Sptlc1

  • We employed myriocin, a specific inhibitor of serine palmitoyl-CoA transferase that mediates the first commitment step in sphingolipid synthesis [3].
  • Enzymatic assays revealed that ceramide synthase activity remained unaltered, whereas serine palmitoyltransferase (SPT), a key enzyme in ceramide synthesis, was activated approximately 2.5-fold by RA treatment [4].
  • After 24 h of treatment of primary cerebellar neurons with the various sphingosine analogues the relative percentage of the respective intracellular 1-phosphate derivatives paralleled exactly the inhibitory effect on serine palmitoyltransferase activity observed when cells were treated with the unphosphorylated compounds [5].
  • In our previous study, the sphingosine-like immunosuppressant, ISP-1, was found to suppress the proliferation of an interleukin-2-dependent cytotoxic T cell line, CTLL-2, through the inhibition of serine palmitoyltransferase, which catalyzes the committed step of sphingolipid biosynthesis [6].
  • The ISP-1-induced apoptosis was inhibited by the addition of sphingosine (2 microM), suggesting that this ISP-1-induced apoptosis is triggered by the decrease in the intracellular levels of sphingolipids caused by the inhibition of serine palmitoyltransferase [6].

Biological context of Sptlc1


Anatomical context of Sptlc1


Associations of Sptlc1 with chemical compounds


Other interactions of Sptlc1


  1. Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Hanada, K. Biochim. Biophys. Acta (2003) [Pubmed]
  2. Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model. Umehara, T., Sudoh, M., Yasui, F., Matsuda, C., Hayashi, Y., Chayama, K., Kohara, M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  3. A novel role for sphingolipid intermediates in activation-induced cell death in T cells. Solomon, J.C., Sharma, K., Wei, L.X., Fujita, T., Shi, Y.F. Cell Death Differ. (2003) [Pubmed]
  4. Production of ceramides causes apoptosis during early neural differentiation in vitro. Herget, T., Esdar, C., Oehrlein, S.A., Heinrich, M., Schütze, S., Maelicke, A., van Echten-Deckert, G. J. Biol. Chem. (2000) [Pubmed]
  5. cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. van Echten-Deckert, G., Zschoche, A., Bär, T., Schmidt, R.R., Raths, A., Heinemann, T., Sandhoff, K. J. Biol. Chem. (1997) [Pubmed]
  6. Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2. Nakamura, S., Kozutsumi, Y., Sun, Y., Miyake, Y., Fujita, T., Kawasaki, T. J. Biol. Chem. (1996) [Pubmed]
  7. Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. Mandon, E.C., Ehses, I., Rother, J., van Echten, G., Sandhoff, K. J. Biol. Chem. (1992) [Pubmed]
  8. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Dobrzyn, A., Dobrzyn, P., Lee, S.H., Miyazaki, M., Cohen, P., Asilmaz, E., Hardie, D.G., Friedman, J.M., Ntambi, J.M. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  9. Sphingolipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid bases. Mandon, E.C., van Echten, G., Birk, R., Schmidt, R.R., Sandhoff, K. Eur. J. Biochem. (1991) [Pubmed]
  10. Disruption of sphingolipid homeostasis by myriocin, a mycotoxin, reduces thymic and splenic T-lymphocyte populations. Johnson, V.J., He, Q., Osuchowski, M.F., Sharma, R.P. Toxicology (2004) [Pubmed]
  11. Cycloserine and threo-dihydrosphingosine inhibit TNF-alpha-induced cytotoxicity: evidence for the importance of de novo ceramide synthesis in TNF-alpha signaling. Meyer, S.G., de Groot, H. Biochim. Biophys. Acta (2003) [Pubmed]
  12. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. Merrill, A.H., van Echten, G., Wang, E., Sandhoff, K. J. Biol. Chem. (1993) [Pubmed]
  13. Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in primary cultured cerebellar neurons. Triola, G., Fabrias, G., Dragusin, M., Niederhausen, L., Broere, R., Llebaria, A., van Echten-Deckert, G. Mol. Pharmacol. (2004) [Pubmed]
  14. Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway. Merrill, A.H., Wang, E., Mullins, R.E. Biochemistry (1988) [Pubmed]
  15. Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice. Park, T.S., Panek, R.L., Rekhter, M.D., Mueller, S.B., Rosebury, W.S., Robertson, A., Hanselman, J.C., Kindt, E., Homan, R., Karathanasis, S.K. Atherosclerosis (2006) [Pubmed]
  16. Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes induction of c-myc in mouse liver. He, Q., Johnson, V.J., Osuchowski, M.F., Sharma, R.P. Mycopathologia (2004) [Pubmed]
  17. Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition. He, Q., Riley, R.T., Sharma, R.P. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
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