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Gene Review

Scd1  -  stearoyl-Coenzyme A desaturase 1

Mus musculus

Synonyms: AA589638, AI265570, Acyl-CoA desaturase 1, Delta(9)-desaturase 1, Delta-9 desaturase 1, ...
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Disease relevance of Scd1


High impact information on Scd1


Chemical compound and disease context of Scd1


Biological context of Scd1


Anatomical context of Scd1


Associations of Scd1 with chemical compounds


Regulatory relationships of Scd1


Other interactions of Scd1

  • The SCD1 deficiency rescued hepatic steatosis of the PPARalpha(-/-) mice [3].
  • The promoter sequence of Scd3 reveals similarity with Scd1 in the proximal region but also possesses several distinctive features including the polyunsaturated fatty acid-response element [21].
  • Previously, two members of this gene family, namely, Scd1 and Scd2, have been reported [21].
  • The lipogenic diet fed to mice with a null mutation in the SCD1 gene (SCD-/-) fails to induce the synthesis of triglycerides in liver, despite the induction of expression of SREBP-1 and its target genes, fatty acid synthase and glycerol-3-phosphate acyltransferase [25].
  • The content of phosphatidylcholine (PC) was increased by 40% and the activities of CTP:choline cytidylyltransferase (CCT), the rate-limiting enzyme in de novo PC synthesis, and choline phosphotransferase were increased by 64 and 53%, respectively, in liver of Scd1-/- mice [19].

Analytical, diagnostic and therapeutic context of Scd1

  • By haplotype analysis and direct sequencing of PCR products, we show that this mutation is a new allele of the asebia locus with a naturally occurring mutation in the Scd1 gene (a CCC insertion at nucleotide position 835 in exon 5), which codes for stearoyl-CoA desaturase 1 [26].
  • Furthermore, when the fat-free diet was supplemented with triacylglycerides containing polyunsaturated fatty acids, the transcription of the SCD1 gene and the induction of the SCD1 mRNA were significantly blunted [27].
  • Northern blot analysis revealed that SCD1 mRNA levels were markedly higher than that in control kidneys [28].
  • In control mice, constitutive renal SCD1 expression was low; however, TO-901317 treatment markedly increased SCD1 expression in the outer stripe of the outer medulla as assessed by both in situ hybridization and immunostain [28].
  • The Northern blot and RT-PCR analyses showed that the SCD mRNA was expressed predominantly in the liver, intestine, gill, and muscle, while a lower level was found in the brain [29].


  1. Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. Asilmaz, E., Cohen, P., Miyazaki, M., Dobrzyn, P., Ueki, K., Fayzikhodjaeva, G., Soukas, A.A., Kahn, C.R., Ntambi, J.M., Socci, N.D., Friedman, J.M. J. Clin. Invest. (2004) [Pubmed]
  2. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Biddinger, S.B., Miyazaki, M., Boucher, J., Ntambi, J.M., Kahn, C.R. Diabetes (2006) [Pubmed]
  3. Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha. Miyazaki, M., Dobrzyn, A., Sampath, H., Lee, S.H., Man, W.C., Chu, K., Peters, J.M., Gonzalez, F.J., Ntambi, J.M. J. Biol. Chem. (2004) [Pubmed]
  4. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Dobrzyn, A., Dobrzyn, P., Lee, S.H., Miyazaki, M., Cohen, P., Asilmaz, E., Hardie, D.G., Friedman, J.M., Ntambi, J.M. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  5. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Cohen, P., Miyazaki, M., Socci, N.D., Hagge-Greenberg, A., Liedtke, W., Soukas, A.A., Sharma, R., Hudgins, L.C., Ntambi, J.M., Friedman, J.M. Science (2002) [Pubmed]
  6. Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Chen, C., Shah, Y.M., Morimura, K., Krausz, K.W., Miyazaki, M., Richardson, T.A., Morgan, E.T., Ntambi, J.M., Idle, J.R., Gonzalez, F.J. Cell Metab. (2008) [Pubmed]
  7. Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. Li, Z.Z., Berk, M., McIntyre, T.M., Feldstein, A.E. J. Biol. Chem. (2009) [Pubmed]
  8. Transcriptional regulation of gene expression during adipocyte differentiation. MacDougald, O.A., Lane, M.D. Annu. Rev. Biochem. (1995) [Pubmed]
  9. Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse. Zheng, Y., Eilertsen, K.J., Ge, L., Zhang, L., Sundberg, J.P., Prouty, S.M., Stenn, K.S., Parimoo, S. Nat. Genet. (1999) [Pubmed]
  10. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. Gutiérrez-Juárez, R., Pocai, A., Mulas, C., Ono, H., Bhanot, S., Monia, B.P., Rossetti, L. J. Clin. Invest. (2006) [Pubmed]
  11. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. Jiang, G., Li, Z., Liu, F., Ellsworth, K., Dallas-Yang, Q., Wu, M., Ronan, J., Esau, C., Murphy, C., Szalkowski, D., Bergeron, R., Doebber, T., Zhang, B.B. J. Clin. Invest. (2005) [Pubmed]
  12. Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Chu, K., Miyazaki, M., Man, W.C., Ntambi, J.M. Mol. Cell. Biol. (2006) [Pubmed]
  13. The regulation of hepatic stearoyl-coenzyme A desaturase in obese-hyperglycaemic (ob/ob) mice by food intake and the fatty acid composition of the diet. Enser, M., Roberts, J.L. Biochem. J. (1982) [Pubmed]
  14. The fate and intermediary metabolism of stearic acid. Sampath, H., Ntambi, J.M. Lipids (2005) [Pubmed]
  15. Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet. Flowers, M.T., Groen, A.K., Oler, A.T., Keller, M.P., Choi, Y., Schueler, K.L., Richards, O.C., Lan, H., Miyazaki, M., Kuipers, F., Kendziorski, C.M., Ntambi, J.M., Attie, A.D. J. Lipid Res. (2006) [Pubmed]
  16. Localization of a negative thyroid hormone-response region in hepatic stearoyl-CoA desaturase gene 1. Waters, K.M., Miller, C.W., Ntambi, J.M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  17. Stearoyl-CoA Desaturase-1 Mediates the Pro-lipogenic Effects of Dietary Saturated Fat. Sampath, H., Miyazaki, M., Dobrzyn, A., Ntambi, J.M. J. Biol. Chem. (2007) [Pubmed]
  18. Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms. Miyazaki, M., Dobrzyn, A., Man, W.C., Chu, K., Sampath, H., Kim, H.J., Ntambi, J.M. J. Biol. Chem. (2004) [Pubmed]
  19. Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver. Dobrzyn, A., Dobrzyn, P., Miyazaki, M., Sampath, H., Chu, K., Ntambi, J.M. J. Biol. Chem. (2005) [Pubmed]
  20. beta-Amyloid-specific upregulation of stearoyl coenzyme A desaturase-1 in macrophages. Uryu, S., Tokuhiro, S., Oda, T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  21. Scd3--a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin. Zheng, Y., Prouty, S.M., Harmon, A., Sundberg, J.P., Stenn, K.S., Parimoo, S. Genomics (2001) [Pubmed]
  22. Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol. Bené, H., Lasky, D., Ntambi, J.M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  23. A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver. Knight, B.L., Hebbachi, A., Hauton, D., Brown, A.M., Wiggins, D., Patel, D.D., Gibbons, G.F. Biochem. J. (2005) [Pubmed]
  24. Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Rahman, S.M., Dobrzyn, A., Dobrzyn, P., Lee, S.H., Miyazaki, M., Ntambi, J.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  25. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. Miyazaki, M., Kim, Y.C., Ntambi, J.M. J. Lipid Res. (2001) [Pubmed]
  26. Scd1ab-Xyk: a new asebia allele characterized by a CCC trinucleotide insertion in exon 5 of the stearoyl-CoA desaturase 1 gene in mouse. Lu, Y., Bu, L., Zhou, S., Jin, M., Sundberg, J.P., Jiang, H., Qian, M., Shi, Y., Zhao, G., Kong, X., Hu, L. Mol. Genet. Genomics (2004) [Pubmed]
  27. Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver. Ntambi, J.M. J. Biol. Chem. (1992) [Pubmed]
  28. Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule. Zhang, Y., Zhang, X., Chen, L., Wu, J., Su, D., Lu, W.J., Hwang, M.T., Yang, G., Li, S., Wei, M., Davis, L., Breyer, M.D., Guan, Y. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  29. cDNA nucleotide sequence coding for stearoyl-CoA desaturase and its expression in the zebrafish (Danio rerio) embryo. Hsieh, S.L., Liu, R.W., Wu, C.H., Cheng, W.T., Kuo, C.M. Mol. Reprod. Dev. (2003) [Pubmed]
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