Disease relevance of PRELID1

• Several of the patients also had positive IFA and Weil-Felix reactions to Proteus vulgaris OX19 (PX 19) [1].

High impact information on PRELID1

• Taken together these data: (i) strongly support the notion that the conserved LEA motif represents a phylogenetic link between plants and animals, (ii) reveal a novel molecule whose expression may play a role in the maturation of distinct human tissues, and (iii) suggest that PRELI expression may be important for GC B lymphocytes [2].
• Consistent with this hypothesis, the expression of PRELI is predominant within germinal centers (GC), a stage in which B lymphocytes are under a stressful selection pressure [2].
• PRELI amino acid sequence is 85% similar to the avian px19 protein, expressed within the blood islands and in the liver during avian embryo development [2].
• PRELI and px19 contain tandem repeats (A/TAEKAK) of the late embryogenesis abundant (LEA) motif, characteristic of a group of survival molecules and originally thought to be present only in plant proteins [2].
• PRELI was cloned by screening a B lymphocyte-specific cDNA library with a probe generated by mRNA differential display [2].

Biological context of PRELID1

• Exceptions were pseudogenes ELP and PX19 whose mouse counterparts were not located within the analyzed region [3].
• Interestingly, PRELI expression is high in the fetal liver, a major site for B cell lymphopoiesis, while the mRNA levels in other fetal tissues such as the brain, lung, and kidney are comparatively low [2].

Anatomical context of PRELID1

• Moreover, PRELI is also highly expressed in the adult lymph nodes and peripheral blood leukocytes, further stressing that at the adult stage, PRELI expression may be important during secondary immune responses [2].

References