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Gene Review

APOBEC3C  -  apolipoprotein B mRNA editing enzyme,...

Homo sapiens

Synonyms: A3C, APOBEC1-like, APOBEC1L, ARDC2, ARDC4, ...
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Disease relevance of APOBEC3C

  • In addition, APOBEC3A and APOBEC3C block intracellular retrotransposons and simian immunodeficiency virus (SIV), respectively [1].
  • We report here that two additional APOBEC3 family members, APOBEC3B and APOBEC3C, have potent antiviral activity against simian immuno-deficiency virus (SIV), but not HIV-1 [2].
  • METHODS AND MATERIALS: Sixteen patients with Stage I breast cancer had PBI treatment plans generated using the multiple, noncoplanar photon field technique and the three-field, mixed-modality technique [3].

High impact information on APOBEC3C


Associations of APOBEC3C with chemical compounds

  • We have exploited the fact that APOBEC3C, whilst highly homologous to the C-terminal domain of APOBEC3F, exhibits a distinct target site specificity (preferring Y-C dinucleotides) in order to identify residues in APOBEC3F that might affect its target site specificity [6].


  1. Identification of APOBEC3DE as Another Antiretroviral Factor from the Human APOBEC Family. Dang, Y., Wang, X., Esselman, W.J., Zheng, Y.H. J. Virol. (2006) [Pubmed]
  2. APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication. Yu, Q., Chen, D., König, R., Mariani, R., Unutmaz, D., Landau, N.R. J. Biol. Chem. (2004) [Pubmed]
  3. Dosimetric comparison of two different three-dimensional conformal external beam accelerated partial breast irradiation techniques. Kozak, K.R., Doppke, K.P., Katz, A., Taghian, A.G. Int. J. Radiat. Oncol. Biol. Phys. (2006) [Pubmed]
  4. APOBEC3 proteins inhibit human LINE-1 retrotransposition. Muckenfuss, H., Hamdorf, M., Held, U., Perkovic, M., Löwer, J., Cichutek, K., Flory, E., Schumann, G.G., Münk, C. J. Biol. Chem. (2006) [Pubmed]
  5. Sucrose concentration influences the rate of human oocytes with normal spindle and chromosome configurations after slow-cooling cryopreservation*. Coticchio, G., De Santis, L., Rossi, G., Borini, A., Albertini, D., Scaravelli, G., Alecci, C., Bianchi, V., Nottola, S., Cecconi, S. Hum. Reprod. (2006) [Pubmed]
  6. Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities. Langlois, M.A., Beale, R.C., Conticello, S.G., Neuberger, M.S. Nucleic Acids Res. (2005) [Pubmed]
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