The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

APOBEC3B  -  apolipoprotein B mRNA editing enzyme,...

Homo sapiens

Synonyms: A3B, APOBEC1L, ARCD3, ARP4, DJ742C19.2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of APOBEC3B


High impact information on APOBEC3B

  • Here, we demonstrate that APOBEC3A and APOBEC3B, two members of the APOBEC3 family of human innate antiretroviral resistance factors, can enter the nucleus, where LINE-1 and Alu reverse transcription occurs, and specifically inhibit both LINE-1 and Alu retrotransposition [5].
  • G --> A hypermutated HBV genomes were recovered from transfection experiments involving APOBEC3B, -3C, -3F, and -3G indicating that all four enzymes were able to extensively deaminate cytidine residues in minus-strand DNA [6].
  • We show that normal human liver expresses the mRNAs of APOBEC3B (A3B), APOBEC3C (A3C), A3F, and A3G [7].
  • In addition, lower levels of retrotransposed L1 DNA accumulated in the presence of APOBEC3B and APOBEC3F [8].
  • We now show that the first two complement control protein (CCP) modules of the C4BP alpha-chain, plus the four residues connecting them, are necessary and sufficient for binding a bacterial virulence factor, the Streptococcus pyogenes M4 (Arp4) protein [9].

Biological context of APOBEC3B


Anatomical context of APOBEC3B

  • We demonstrate that APOBEC3C and APOBEC3B were endogenously expressed in HeLa cells [12].
  • These studies therefore raise the possibility that activation of the endogenous APOBEC3B gene in primary human lymphoid cells could form a novel and effective strategy for inhibition of HIV-1 replication in vivo [13].
  • We screened an MCL cDNA expression library with sera at GVL response after allogeneic haematopoietic stem cell transplantation and isolated five genes including APOBEC3B [4].

Other interactions of APOBEC3B


Analytical, diagnostic and therapeutic context of APOBEC3B


  1. APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication. Yu, Q., Chen, D., König, R., Mariani, R., Unutmaz, D., Landau, N.R. J. Biol. Chem. (2004) [Pubmed]
  2. Cytidine deamination of retroviral DNA by diverse APOBEC proteins. Bishop, K.N., Holmes, R.K., Sheehy, A.M., Davidson, N.O., Cho, S.J., Malim, M.H. Curr. Biol. (2004) [Pubmed]
  3. Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases. Mahieux, R., Suspène, R., Delebecque, F., Henry, M., Schwartz, O., Wain-Hobson, S., Vartanian, J.P. J. Gen. Virol. (2005) [Pubmed]
  4. Identification of APOBEC3B as a potential target for the graft-versus-lymphoma effect by SEREX in a patient with mantle cell lymphoma. Hishizawa, M., Imada, K., Sakai, T., Ueda, M., Uchiyama, T. Br. J. Haematol. (2005) [Pubmed]
  5. Cellular inhibitors of long interspersed element 1 and Alu retrotransposition. Bogerd, H.P., Wiegand, H.L., Hulme, A.E., Garcia-Perez, J.L., O'Shea, K.S., Moran, J.V., Cullen, B.R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  6. Extensive editing of both hepatitis B virus DNA strands by APOBEC3 cytidine deaminases in vitro and in vivo. Suspène, R., Guétard, D., Henry, M., Sommer, P., Wain-Hobson, S., Vartanian, J.P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Interferon-inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication. Bonvin, M., Achermann, F., Greeve, I., Stroka, D., Keogh, A., Inderbitzin, D., Candinas, D., Sommer, P., Wain-Hobson, S., Vartanian, J.P., Greeve, J. Hepatology (2006) [Pubmed]
  8. APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. Stenglein, M.D., Harris, R.S. J. Biol. Chem. (2006) [Pubmed]
  9. Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor. Jenkins, H.T., Mark, L., Ball, G., Persson, J., Lindahl, G., Uhrin, D., Blom, A.M., Barlow, P.N. J. Biol. Chem. (2006) [Pubmed]
  10. Functional central polypurine tract provides downstream protection of the human immunodeficiency virus type 1 genome from editing by APOBEC3G and APOBEC3B. Wurtzer, S., Goubard, A., Mammano, F., Saragosti, S., Lecossier, D., Hance, A.J., Clavel, F. J. Virol. (2006) [Pubmed]
  11. Comparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasites. Gordon, J.L., Sibley, L.D. BMC Genomics (2005) [Pubmed]
  12. APOBEC3 proteins inhibit human LINE-1 retrotransposition. Muckenfuss, H., Hamdorf, M., Held, U., Perkovic, M., Löwer, J., Cichutek, K., Flory, E., Schumann, G.G., Münk, C. J. Biol. Chem. (2006) [Pubmed]
  13. Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif. Doehle, B.P., Schäfer, A., Cullen, B.R. Virology (2005) [Pubmed]
  14. Identification of APOBEC3DE as Another Antiretroviral Factor from the Human APOBEC Family. Dang, Y., Wang, X., Esselman, W.J., Zheng, Y.H. J. Virol. (2006) [Pubmed]
  15. APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells. Bogerd, H.P., Wiegand, H.L., Doehle, B.P., Lueders, K.K., Cullen, B.R. Nucleic Acids Res. (2006) [Pubmed]
  16. Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells. Sung, T.L., Rice, A.P. Retrovirology (2006) [Pubmed]
  17. Renal cell carcinoma in acquired renal cystic disease 3 years after successful kidney transplantation. Two case reports and review of the literature. Banyai-Falger, S., Susani, M., Maier, U. Eur. Urol. (1995) [Pubmed]
WikiGenes - Universities