Disease relevance of D0H4S114

• Intriguingly, P311 gene expression was significantly decreased in lungs of individuals with emphysema compared with control subjects [1].

Psychiatry related information on D0H4S114

• Together our data suggest that P311 expression is tightly regulated during the critical periods of alveolar formation, and that under pathologic conditions, its relative absence may contribute to failure of alveolar regeneration and lead to the development of human emphysema [1].

High impact information on D0H4S114

• Consistent with a role for this gene in alveolar formation, inhibition of alveolization by dexamethasone treatment in vivo resulted in decreased expression of P311 [1].
• P311, a putative neuronal protein originally identified for its high expression in late-stage embryonic brain, was highly differentially expressed during periods of active distal lung morphogenesis [1].
• This suggested that P311 downregulates TGF-beta1 and 2 in part by blocking TGF-beta autoinduction [2].
• We recently showed that expression of P311 in NIH 3T3 cells induced a myofibroblast phenotype with low TGF-beta1 expression [2].
• To determine the molecular mechanism of regulation of pentylenetetrazol (PTZ)-induced calcium entry by the seizure-related gene, PTZ-17, the role of the 3'-untranslated region (3'UTR) and also interaction between 3'UTR and intracellular factors were investigated [3].

Anatomical context of D0H4S114

• Injection of PTZ-17 derived RNA into Xenopus oocytes showed a large calcium inward current with extracellular application of pentylenetetrazol [4].

Associations of D0H4S114 with chemical compounds

• Cloning and characterization of pentylenetetrazol-related cDNA, PTZ-17 [4].
• They were cytosolic phospholipase A2, 78 kDa glucose regulated protein, SEZ-15 which has an EF hand motif and PTZ-17 that causes calcium current in Xenopus oocyte with PTZ application [5].

Other interactions of D0H4S114

• Deletion of the PEST domain reversed the effect of P311 on TGF-beta isoforms [2].

Analytical, diagnostic and therapeutic context of D0H4S114

• Quantitative real-time RT-PCR showed that the expression of P311 is developmentally regulated, with peak levels occurring during saccular and alveolar formation [1].

References