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Gene Review

NSs  -  non-structural protein

Oropouche virus

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Disease relevance of NSs

  • Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis [1].
  • The smallest RNA segment, S, encodes the nucleocapsid protein N and a nonstructural protein, NSs, in overlapping reading frames [1].
  • In addition, the abrogation of NSs expression changed Bunyamwera virus from a noninducer to an inducer of an interferon-beta promoter [1].
  • We have recently identified the nonstructural protein NSs of Bunyamwera virus (BUNV), the prototype of the family Bunyaviridae, as a virulence factor that blocks the induction of IFN by dsRNA [2].

High impact information on NSs

  • We have generated a mutant virus lacking NSs, called BUNdelNSs, by reverse genetics [1].
  • Here, we demonstrate that NSs targets the RNA polymerase II (RNAP II) complex [3].
  • However, NSs prevented CTD phosphorylation at serine 2, suggesting a block in transition from initiation to elongation [3].
  • Here, we show that the ability to inhibit both host transcription and the interferon response is linked to interaction of NSs with the MED8 component of Mediator, a protein complex necessary for mRNA production [4].
  • In agreement with previously published data concerning CAL serogroup viruses, the nucleocapsid (N) and non-structural (NSs) proteins were encoded in over-lapping open reading frames (ORFs) [5].

Biological context of NSs

  • The NSs ORFs were either 279 or 294 nucleotides in length, which would encode 92 or 97 amino-acid proteins, respectively [5].


  1. Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis. Bridgen, A., Weber, F., Fazakerley, J.K., Elliott, R.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs. Streitenfeld, H., Boyd, A., Fazakerley, J.K., Bridgen, A., Elliott, R.M., Weber, F. J. Virol. (2003) [Pubmed]
  3. Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonist. Thomas, D., Blakqori, G., Wagner, V., Banholzer, M., Kessler, N., Elliott, R.M., Haller, O., Weber, F. J. Biol. Chem. (2004) [Pubmed]
  4. Interaction of Bunyamwera Orthobunyavirus NSs Protein with Mediator Protein MED8: a Mechanism for Inhibiting the Interferon Response. Léonard, V.H., Kohl, A., Hart, T.J., Elliott, R.M. J. Virol. (2006) [Pubmed]
  5. The S RNA genomic sequences of Inkoo, San Angelo, Serra do Navio, South River and Tahyna bunyaviruses. Huang, C., Shope, R.E., Spargo, B., Campbell, W.P. J. Gen. Virol. (1996) [Pubmed]
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