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Gene Review

P  -  P

Human metapneumovirus

 
 
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Disease relevance of P

 

High impact information on P

  • In African green monkeys immunized intranasally and intratracheally, the mean peak titer of the P chimera was reduced 100- and 1,000-fold in the upper and lower respiratory tracts, whereas the N chimera was reduced only 10-fold in the lower respiratory tract [2].
  • In a first evaluation of 20 viral cultures with characteristics compatible with hMPV cytopathic effect, the PCR positivity rates were 100, 90, 75, 60, and 55% using primers for the N, L, M, P, and F genes [1].
  • Avian metapneumovirus phosphoprotein targeted RNA interference silences the expression of viral proteins and inhibits virus replication [3].
  • For both the P and M2-1 protein-predicted amino acid sequences, aMPV/B was most similar to aMPV/A (72 and 89% identity, respectively), having only approximately 52 and 70% identity, respectively, relative to aMPV/C and hMPV [4].
  • Subtype B avian metapneumovirus resembles subtype A more closely than subtype C or human metapneumovirus with respect to the phosphoprotein, and second matrix and small hydrophobic proteins [4].
 

Analytical, diagnostic and therapeutic context of P

References

  1. Comparative evaluation of real-time PCR assays for detection of the human metapneumovirus. Côté, S., Abed, Y., Boivin, G. J. Clin. Microbiol. (2003) [Pubmed]
  2. Chimeric recombinant human metapneumoviruses with the nucleoprotein or phosphoprotein open reading frame replaced by that of avian metapneumovirus exhibit improved growth in vitro and attenuation in vivo. Pham, Q.N., Biacchesi, S., Skiadopoulos, M.H., Murphy, B.R., Collins, P.L., Buchholz, U.J. J. Virol. (2005) [Pubmed]
  3. Avian metapneumovirus phosphoprotein targeted RNA interference silences the expression of viral proteins and inhibits virus replication. Munir, S., Kaur, K., Kapur, V. Antiviral Res. (2006) [Pubmed]
  4. Subtype B avian metapneumovirus resembles subtype A more closely than subtype C or human metapneumovirus with respect to the phosphoprotein, and second matrix and small hydrophobic proteins. Jacobs, J.A., Njenga, M.K., Alvarez, R., Mawditt, K., Britton, P., Cavanagh, D., Seal, B.S. Virus Res. (2003) [Pubmed]
  5. Comparison of avian cell substrates for propagating subtype C avian metapneumovirus. Kong, B.W., Foster, L.K., Foster, D.N. Virus Res. (2006) [Pubmed]
  6. Use of the P gene to genotype human metapneumovirus identifies 4 viral subtypes. Mackay, I.M., Bialasiewicz, S., Waliuzzaman, Z., Chidlow, G.R., Fegredo, D.C., Laingam, S., Adamson, P., Harnett, G.B., Rawlinson, W., Nissen, M.D., Sloots, T.P. J. Infect. Dis. (2004) [Pubmed]
 
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