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Gene Review

cdh2  -  cadherin 2, type 1, N-cadherin (neuronal)

Danio rerio

Synonyms: Cadherin-2, N-cadherin, Neural cadherin, SO:0000704, ZNCAD, ...
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Disease relevance of cdh2


High impact information on cdh2

  • Through the direct analysis of cell behaviors, we address the mechanisms underlying anterior neural tube morphogenesis in the zebrafish and the role of the cell adhesion molecule N-cadherin (N-cad) in this process [2].
  • Although in vitro studies have implicated Fgf receptors in modulating the axon outgrowth promoting properties of Ncad, most aspects of the Ncad mutant phenotype are not phenocopied by treatments that block Fgf receptor function [3].
  • N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neurites [3].
  • Although the location of cell division is disorganized in embryos with reduced or no Ncad function, different classes of retinal neurons are generated [3].
  • Our results thus highlight novel and crucial in vivo roles for Ncad in the control of cell convergence, maintenance of neuronal positioning and dorsal cell proliferation during vertebrate neural tube development [4].

Biological context of cdh2


Anatomical context of cdh2


Analytical, diagnostic and therapeutic context of cdh2


  1. Assembly of trigeminal sensory ganglia by chemokine signaling. Knaut, H., Blader, P., Strähle, U., Schier, A.F. Neuron (2005) [Pubmed]
  2. N-cadherin is required for the polarized cell behaviors that drive neurulation in the zebrafish. Hong, E., Brewster, R. Development (2006) [Pubmed]
  3. N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neurites. Masai, I., Lele, Z., Yamaguchi, M., Komori, A., Nakata, A., Nishiwaki, Y., Wada, H., Tanaka, H., Nojima, Y., Hammerschmidt, M., Wilson, S.W., Okamoto, H. Development (2003) [Pubmed]
  4. parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube. Lele, Z., Folchert, A., Concha, M., Rauch, G.J., Geisler, R., Rosa, F., Wilson, S.W., Hammerschmidt, M., Bally-Cuif, L. Development (2002) [Pubmed]
  5. Up-regulation of cadherin-2 and cadherin-4 in regenerating visual structures of adult zebrafish. Liu, Q., Londraville, R.L., Azodi, E., Babb, S.G., Chiappini-Williamson, C., Marrs, J.A., Raymond, P.A. Exp. Neurol. (2002) [Pubmed]
  6. N-cadherin is essential for retinal lamination in the zebrafish. Erdmann, B., Kirsch, F.P., Rathjen, F.G., Moré, M.I. Dev. Dyn. (2003) [Pubmed]
  7. Differential expression of cadherins in the developing and adult zebrafish olfactory system. Liu, Q., Marrs, J.A., Azodi, E., Kerstetter, A.E., Babb, S.G., Hashmi, L. J. Comp. Neurol. (2004) [Pubmed]
  8. Cadherin-2 function in the cranial ganglia and lateral line system of developing zebrafish. Kerstetter, A.E., Azodi, E., Marrs, J.A., Liu, Q. Dev. Dyn. (2004) [Pubmed]
  9. Cadherin-1, -2, and -11 expression and cadherin-2 function in the pectoral limb bud and fin of the developing zebrafish. Liu, Q., Kerstetter, A.E., Azodi, E., Marrs, J.A. Dev. Dyn. (2003) [Pubmed]
  10. Differential expression of cadherin-2 and cadherin-4 in the developing and adult zebrafish visual system. Liu, Q., Babb, S.G., Novince, Z.M., Doedens, A.L., Marrs, J., Raymond, P.A. Vis. Neurosci. (2001) [Pubmed]
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