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Gene Review

MYF5  -  myogenic factor 5

Bos taurus

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Disease relevance of MYF5

  • To study the role of myf5 in vivo, we generated transgenic mice harboring the bovine homolog, bmyf, under control of the murine sarcoma virus promoter [1].

High impact information on MYF5

  • Expression of bovine myf5 induces ectopic skeletal muscle formation in transgenic mice [1].
  • Myf-5 is expressed in proliferating myoblasts [2].
  • Other SNP of igf1 and myf5 or other genes in their respective chromosomal regions, however, should also be studied [3].
  • During frostbite-induced muscle regeneration, gene expression for myostatin and 4 MRF; i.e., Myf5, MyoD, myogenin and MRF4, showed contrasting responses [4].
  • The results suggest that MyoD and Myf5 influence the MyHC isoform expression, although the effects are not decisive in specifying the phenotypes of adult muscles [5].

Biological context of MYF5


Anatomical context of MYF5


Analytical, diagnostic and therapeutic context of MYF5

  • To investigate the relationships between MyHC isoforms and myogenic regulatory factors (MRFs) including MyoD, Myf5, myogenin, and MRF4 in adult skeletal muscles, expressions of these MRFs in the ten muscles of three cows were analyzed by a semi-quantitative RT-PCR [5].


  1. Expression of bovine myf5 induces ectopic skeletal muscle formation in transgenic mice. Santerre, R.F., Bales, K.R., Janney, M.J., Hannon, K., Fisher, L.F., Bailey, C.S., Morris, J., Ivarie, R., Smith, C.K. Mol. Cell. Biol. (1993) [Pubmed]
  2. Genetic variation at the porcine MYF-5 gene locus. Lack Of association with meat production traits. te Pas, M.F., Harders, F.L., Soumillion, A., Born, L., Buist, W., Meuwissen, T.H. Mamm. Genome (1999) [Pubmed]
  3. Assessment of positional candidate genes myf5 and igf1 for growth on bovine chromosome 5 in commercial lines of Bos taurus. Li, C., Basarab, J., Snelling, W.M., Benkel, B., Murdoch, B., Hansen, C., Moore, S.S. J. Anim. Sci. (2004) [Pubmed]
  4. Gene expression of myostatin during development and regeneration of skeletal muscle in Japanese Black Cattle. Shibata, M., Matsumoto, K., Aikawa, K., Muramoto, T., Fujimura, S., Kadowaki, M. J. Anim. Sci. (2006) [Pubmed]
  5. Related expression of MyoD and Myf5 with myosin heavy chain isoform types in bovine adult skeletal muscles. Muroya, S., Nakajima, I., Chikuni, K. Zool. Sci. (2002) [Pubmed]
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