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Gene Review

myf5  -  myogenic factor 5

Danio rerio

Synonyms: SO:0000704, cb641, myf-5, zgc:110509
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High impact information on myf5

  • In the absence of Fgf8, lateral somite cells transiently express myf5 but fail to make muscle and remain in a dermomyotome-like state characterised by pax3 and meox expression [1].
  • Knocking down foxd3 with morpholino oligonucleotide (MO) resulted in a dramatic down-regulation of myf5 in somites and adaxial cells but not in the presomitic mesoderm [2].
  • Foxd3 mediation of myf5 expression is stage-dependent, maintaining myf5 expression in the somites and adaxial cells during the 7- to 18-somite stage [2].
  • This report is the first study to show that Foxd3, a well-known regulator in neural crest development, is also involved in myf5 regulation [2].
  • On the basis of the expression patterns of myf5 and myod, we propose a model to present how Myf5 and Myod are involved in head myogenesis of zebrafish [3].

Biological context of myf5


Anatomical context of myf5

  • We observed that zebrafish myf5 was detected in the primordia of the obliques, lateral rectus, sternohyoideus, and pharyngeal mesoderm cores [3].

Other interactions of myf5

  • The expression dynamics of myf5 in presomitic and somitic mesoderm suggest that RA promotes muscle differentiation, a role supported by the fact that RA activates expression of fast myosin, while DEAB represses it [7].

Analytical, diagnostic and therapeutic context of myf5


  1. Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish. Groves, J.A., Hammond, C.L., Hughes, S.M. Development (2005) [Pubmed]
  2. Foxd3 mediates zebrafish myf5 expression during early somitogenesis. Lee, H.C., Huang, H.Y., Lin, C.Y., Chen, Y.H., Tsai, H.J. Dev. Biol. (2006) [Pubmed]
  3. Myogenic regulatory factors Myf5 and Myod function distinctly during craniofacial myogenesis of zebrafish. Lin, C.Y., Yung, R.F., Lee, H.C., Chen, W.T., Chen, Y.H., Tsai, H.J. Dev. Biol. (2006) [Pubmed]
  4. Multiple upstream modules regulate zebrafish myf5 expression. Chen, Y.H., Wang, Y.H., Chang, M.Y., Lin, C.Y., Weng, C.W., Westerfield, M., Tsai, H.J. BMC Dev. Biol. (2007) [Pubmed]
  5. Novel cis-element in intron 1 represses somite expression of zebrafish myf-5. Lin, C.Y., Chen, Y.H., Lee, H.C., Tsai, H.J. Gene (2004) [Pubmed]
  6. Molecular structure, dynamic expression, and promoter analysis of zebrafish (Danio rerio) myf-5 gene. Chen, Y.H., Lee, W.C., Liu, C.F., Tsai, H.J. Genesis (2001) [Pubmed]
  7. Retinoic acid activates myogenesis in vivo through Fgf8 signalling. Hamade, A., Deries, M., Begemann, G., Bally-Cuif, L., Genêt, C., Sabatier, F., Bonnieu, A., Cousin, X. Dev. Biol. (2006) [Pubmed]
  8. Novel regulatory sequence -82/-62 functions as a key element to drive the somite-specificity of zebrafish myf-5. Chen, Y.H., Lee, H.C., Liu, C.F., Lin, C.Y., Tsai, H.J. Dev. Dyn. (2003) [Pubmed]
  9. Functional analysis of the proximal promoter regions of fish rhodopsin and myf-5 genes using transgenesis. Wang, T.M., Chen, Y.H., Liu, C.F., Tsai, H.J. Mar. Biotechnol. (2002) [Pubmed]
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