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Gene Review

PIGR  -  polymeric immunoglobulin receptor

Bos taurus

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Disease relevance of PIGR


High impact information on PIGR


Biological context of PIGR


Anatomical context of PIGR


Analytical, diagnostic and therapeutic context of PIGR

  • In Northern blot analysis of various bovine tissues, only the long form of pIgR mRNA was detected [5].
  • Direct PCR sequencing of a segment in the PIGR coding region (nucleotides 162-413) from 13 bulls of Norwegian Cattle revealed single nucleotide exchanges at two positions [6].


  1. A polymeric immunoglobulin receptor-like milk protein with inhibitory activity on human immunodeficiency virus type 1 reverse transcriptase. Ng, T.B., Ye, X.Y. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  2. Selective inhibition of transcytosis by brefeldin A in MDCK cells. Hunziker, W., Whitney, J.A., Mellman, I. Cell (1991) [Pubmed]
  3. Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits. Chang, M.P., Mallet, W.G., Mostov, K.E., Brodsky, F.M. EMBO J. (1993) [Pubmed]
  4. The IgA/IgM receptor expressed on a murine B cell lymphoma is poly-Ig receptor. Phillips-Quagliata, J.M., Patel, S., Han, J.K., Arakelov, S., Rao, T.D., Shulman, M.J., Fazel, S., Corley, R.B., Everett, M., Klein, M.H., Underdown, B.J., Corthésy, B. J. Immunol. (2000) [Pubmed]
  5. Cloning and characterization of two forms of bovine polymeric immunoglobulin receptor cDNA. Kulseth, M.A., Krajci, P., Myklebost, O., Rogne, S. DNA Cell Biol. (1995) [Pubmed]
  6. Chromosomal localization and detection of DNA polymorphisms in the bovine polymeric immunoglobulin receptor gene. Kulseth, M.A., Toldo, S.S., Fries, R., Womack, J., Lien, S., Rogne, S. Anim. Genet. (1994) [Pubmed]
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