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Gene Review

Pigr  -  polymeric immunoglobulin receptor

Mus musculus

Synonyms: PIgR, Poly-Ig receptor, Polymeric immunoglobulin receptor
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The polymeric Immunoglobulin Receptor (pIgR), initially known as "Secretory Component" (SC) in the early literature, is expressed on mucosal epithelial cells where it binds and transports polymeric IgM and dimeric IgA across the epithelial barrier and out to the mucosal secretions [1].


Disease relevance of Pigr

  • Contribution of polymeric immunoglobulin receptor to regulation of intestinal inflammation in dextran sulfate sodium-induced colitis [2].
  • Additionally, colonic tissues from the pIgR(-/-) mice exhibited progressively and significantly greater degrees of mucosal edema, ulceration, crypt abscesses and macrophage infiltration when compared to similarly treated IgA(-/-) mice and wild-type animals [2].
  • Mesangial IgA in IgA nephropathy are dimers with a J chain but no poly-Ig receptor [3].

High impact information on Pigr


Biological context of Pigr


Anatomical context of Pigr

  • PCR amplification of liver progenitor cell chromosomal (rat and mouse Pigr, rat INS1, mouse INS2) and mitochondrial (rat and mouse COX1) genes revealed only mouse sequences [13].
  • The pIgR is consumed during the transcytosis of dIgA and is cleaved at the apical side of the epithelial cells, regardless of the binding to its ligand (dIgA), to form secretory component (SC) [14].
  • Four transgenic lines were made, expressing the pIgR construct at RNA and protein level only in their mammary glands [14].
  • A high level of poly-Ig receptor or Thy-1 mRNA accumulation was observed in MDCK cells in response to dexamethasone with a parallel ten- to 200-fold increase in protein synthesis depending on the recombinant protein and the transfected cell clone [15].
  • Taken together, our findings suggest that dietary FOS increases the intestinal IgA response and pIgR expression in the small intestine as well as the colon in infant mice [16].

Associations of Pigr with chemical compounds

  • Moreover, tunicamycin treatment revealed the core form of pIgR had a molecular mass of approximately 100 kDa [10].
  • It was found that dextran sulfate sodium-treated pIgR(-/-) mice displayed greater loss of bodyweight and had severe clinical illness compared to similarly treated IgA(-/-) mice and wild-type animals [2].
  • We found a repetition of CA dinucleotides on the second intron of mouse polymeric immunoglobulin receptor (PIgR) gene [17].

Analytical, diagnostic and therapeutic context of Pigr

  • Western blotting and metabolic labeling experiments followed by immunoprecipitation with an anti-mouse secretory component (SC) Ab demonstrated the existence of a 110 kDa immature form of pIgR [10].
  • Using RT-PCR we also show that mRNA for the polymeric immunoglobulin receptor (PIgR), which transports IgA across mucosal epithelia, is expressed only in the prostate but not in other regions of the male reproductive ducts upstream of the prostate [18].


  1. Regulation of the formation and external transport of secretory immunoglobulins. Norderhaug, I.N., Johansen, F.E., Schjerven, H., Brandtzaeg, P. Crit. Rev. Immunol. (1999) [Pubmed]
  2. Contribution of polymeric immunoglobulin receptor to regulation of intestinal inflammation in dextran sulfate sodium-induced colitis. Murthy, A.K., Dubose, C.N., Banas, J.A., Coalson, J.J., Arulanandam, B.P. J. Gastroenterol. Hepatol. (2006) [Pubmed]
  3. Back-pack mice as a model of renal mesangial IgA dimers deposition. Kennel-De March, A., Prin-Mathieu, C., Kohler, C.H., Kolopp-Sarda, M.N., Faure, G.C., Béné, M.V. International journal of immunopathology and pharmacology. (2005) [Pubmed]
  4. Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice. Johansen, F.E., Pekna, M., Norderhaug, I.N., Haneberg, B., Hietala, M.A., Krajci, P., Betsholtz, C., Brandtzaeg, P. J. Exp. Med. (1999) [Pubmed]
  5. Functional expression of the polymeric immunoglobulin receptor from cloned cDNA in fibroblasts. Deitcher, D.L., Neutra, M.R., Mostov, K.E. J. Cell Biol. (1986) [Pubmed]
  6. Accumulation of intestinal intraepithelial lymphocytes in association with lack of polymeric immunoglobulin receptor. Yamazaki, K., Shimada, S., Kato-Nagaoka, N., Soga, H., Itoh, T., Nanno, M. Eur. J. Immunol. (2005) [Pubmed]
  7. Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor. Jackson, D.G., Hart, D.N., Starling, G., Bell, J.I. Eur. J. Immunol. (1992) [Pubmed]
  8. Vitamin A deficiency has different effects on immunoglobulin A production and transport during influenza A infection in BALB/c mice. Gangopadhyay, N.N., Moldoveanu, Z., Stephensen, C.B. J. Nutr. (1996) [Pubmed]
  9. Over-expression of the murine pIgR gene in the mammary gland of transgenic mice influences the milk composition and reduces its nutritional value. de Groot, N., van Kuik-Romeijn, P., Lee, S.H., de Boer, H.A. Transgenic Res. (2001) [Pubmed]
  10. Molecular maturation and functional expression of mouse polymeric immunoglobulin receptor. Asano, M., Saito, M., Fujita, H., Wada, M., Kobayashi, K., Vaerman, J.P., Moro, I. J. Immunol. Methods (1998) [Pubmed]
  11. Active synthesis of mouse polymeric immunoglobulin receptor in the epithelial cells of the distal urinary tubule in kidney. Asano, M., Saito, M., Suguro, H., Nomura, H., Inage, T., Moro, I. Scand. J. Immunol. (2004) [Pubmed]
  12. Molecular and functional characteristics of the Fcalpha/muR, a novel Fc receptor for IgM and IgA. Shibuya, A., Honda, S. Springer Semin. Immunopathol. (2006) [Pubmed]
  13. Hepatic progenitor cell lines from allyl alcohol-treated adult rats are derived from gamma-irradiated mouse STO cells. Zhang, M., Sell, S., Leffert, H.L. Stem Cells (2003) [Pubmed]
  14. Over-expression of the murine polymeric immunoglobulin receptor gene in the mammary gland of transgenic mice. de Groot, N., van Kuik-Romeijn, P., Lee, S.H., de Boer, H.A. Transgenic Res. (1999) [Pubmed]
  15. Highly inducible synthesis of heterologous proteins in epithelial cells carrying a glucocorticoid-responsive vector. Hirt, R.P., Poulain-Godefroy, O., Billotte, J., Kraehenbuhl, J.P., Fasel, N. Gene (1992) [Pubmed]
  16. Dietary fructooligosaccharides up-regulate immunoglobulin A response and polymeric immunoglobulin receptor expression in intestines of infant mice. Nakamura, Y., Nosaka, S., Suzuki, M., Nagafuchi, S., Takahashi, T., Yajima, T., Takenouchi-Ohkubo, N., Iwase, T., Moro, I. Clin. Exp. Immunol. (2004) [Pubmed]
  17. Mapping of mouse polymeric immunoglobulin receptor (PIgR) gene using simple sequence length polymorphism markers. Sato, T. Genes Genet. Syst. (1998) [Pubmed]
  18. Intranasal immunization with C. muridarum major outer membrane protein (MOMP) and cholera toxin elicits local production of neutralising IgA in the prostate. Hickey, D.K., Jones, R.C., Bao, S., Blake, A.E., Skelding, K.A., Berry, L.J., Beagley, K.W. Vaccine (2004) [Pubmed]
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