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Gene Review

TLR3  -  toll-like receptor 3

Bos taurus

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High impact information on TLR3

  • Predicted protein structures of buffalo and nilgai TLR3 from deduced amino acid sequences indicate that the buffalo and nilgai TLR3 ectodomain may be more efficient in ligand binding than that of cattle [1].
  • Sequence analysis reveals that 2,715-bp-long TLR3 open reading frame encoding 904 amino acids in buffalo as well as nilgai is similar to that of cattle [1].
  • Toll-like receptor 3 (TLR3), an antiviral innate immunity receptor recognizes double-stranded RNA, preferably of viral origin and induces type I interferon production, which causes maturation of phagocytes and subsequent release of chemical mediators from phagocytes against some viral infections [1].
  • Thus, the amount of TLR2, TLR3 and TLR4 mRNA transcripts is stable at least under the conditions tested [2].

Analytical, diagnostic and therapeutic context of TLR3

  • Furthermore, TLR3 messenger RNA expression in tissues as quantified by real-time PCR was found higher in nilgai than buffalo [1].


  1. Molecular characterization of coding sequences and analysis of Toll-like receptor 3 mRNA expression in water buffalo (Bubalus bubalis) and nilgai (Boselaphus tragocamelus). Dhara, A., Saini, M., Das, D.K., Swarup, D., Sharma, B., Kumar, S., Gupta, P.K. Immunogenetics (2007) [Pubmed]
  2. Evidence for dissociation of TLR mRNA expression and TLR agonist-mediated functions in bovine macrophages. Franchini, M., Schweizer, M., Mätzener, P., Magkouras, I., Sauter, K.S., Mirkovitch, J., Peterhans, E., Jungi, T.W. Vet. Immunol. Immunopathol. (2006) [Pubmed]
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