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Gene Review

Tlr3  -  toll-like receptor 3

Rattus norvegicus

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Disease relevance of Tlr3


High impact information on Tlr3


Biological context of Tlr3

  • On the other hand, dsRNA plus IFN-gamma does not induce apoptosis in INS-1E cells, and expression of TLR3 and type I IFNs mRNAs is not detected in these cells [2].
  • Using Western blot analysis and real-time qPCR, we determined that neonatal rat astrocyte cultures constitutively express TLR3 mRNA and protein, and that PIC dsRNA induced phosphorylation of eIF2alpha, as well as mRNA type I interferon (alpha/beta IFN)-response genes Mx1, PKR, and TLR3 [4].

Anatomical context of Tlr3

  • Astrocyte TLR3 protein was downregulated after PIC treatment, however [4].

Analytical, diagnostic and therapeutic context of Tlr3


  1. The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. Blankenhorn, E.P., Rodemich, L., Martin-Fernandez, C., Leif, J., Greiner, D.L., Mordes, J.P. Diabetes (2005) [Pubmed]
  2. Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells. Rasschaert, J., Ladrière, L., Urbain, M., Dogusan, Z., Katabua, B., Sato, S., Akira, S., Gysemans, C., Mathieu, C., Eizirik, D.L. J. Biol. Chem. (2005) [Pubmed]
  3. LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation. Mordes, J.P., Guberski, D.L., Leif, J.H., Woda, B.A., Flanagan, J.F., Greiner, D.L., Kislauskis, E.H., Tirabassi, R.S. Diabetes (2005) [Pubmed]
  4. Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes. Scumpia, P.O., Kelly, K.M., Reeves, W.H., Stevens, B.R. Glia (2005) [Pubmed]
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