Gene Review:
TLR3 - toll-like receptor 3
Macaca mulatta
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Disease relevance of TLR3
- Increased expression of TLR3 in lymph nodes during simian immunodeficiency virus infection: implications for inflammation and immunodeficiency [1].
- These findings identify roles for TLR3 inflammation in lymphoid tissues and in the immunopathogenesis of HIV-1/SIV, and suggest that TLR3 ligands could potentially be used to flush out latently infected cells that persist during antiretroviral therapies [1].
Analytical, diagnostic and therapeutic context of TLR3
- By real-time RT-PCR, TLR3 was determined to be up-regulated in macaque lymph nodes (LN) throughout the course of infection, whereas TLR9 was down-regulated during early stages of infection [1].
References
- Increased expression of TLR3 in lymph nodes during simian immunodeficiency virus infection: implications for inflammation and immunodeficiency. Sanghavi, S.K., Reinhart, T.A. J. Immunol. (2005) [Pubmed]
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