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Gene Review

Tlr3  -  toll-like receptor 3

Mus musculus

Synonyms: AI957183, Toll-like receptor 3
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Disease relevance of Tlr3


High impact information on Tlr3


Chemical compound and disease context of Tlr3


Biological context of Tlr3


Anatomical context of Tlr3


Associations of Tlr3 with chemical compounds


Other interactions of Tlr3


Analytical, diagnostic and therapeutic context of Tlr3

  • Tlr3-deficient (Tlr3(-/-)) mice were more resistant to lethal WNV infection and had impaired cytokine production and enhanced viral load in the periphery, whereas in the brain, viral load, inflammatory responses and neuropathology were reduced compared to wild-type mice [2].
  • A clinical trial employing an immunotherapeutic approach based on the use of a Toll-like receptor 3 (TLR3) agonist and tumour-derived exosomes carrying tumour-associated antigens is planned in advanced ovarian cancer in conjunction with conventional first line chemotherapy [18].


  1. Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. Patole, P.S., Gröne, H.J., Segerer, S., Ciubar, R., Belemezova, E., Henger, A., Kretzler, M., Schlöndorff, D., Anders, H.J. J. Am. Soc. Nephrol. (2005) [Pubmed]
  2. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Wang, T., Town, T., Alexopoulou, L., Anderson, J.F., Fikrig, E., Flavell, R.A. Nat. Med. (2004) [Pubmed]
  3. Enlarged Spleens Without Enlarged Lymph Nodes in tlr3(/) pkr(/) Mice. White, C.L., Whitmore, M.M., Williams, B.R. J. Interferon Cytokine Res. (2007) [Pubmed]
  4. TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment. Orinska, Z., Bulanova, E., Budagian, V., Metz, M., Maurer, M., Bulfone-Paus, S. Blood (2005) [Pubmed]
  5. Double-stranded RNA-mediated TLR3 activation is enhanced by CD14. Lee, H.K., Dunzendorfer, S., Soldau, K., Tobias, P.S. Immunity (2006) [Pubmed]
  6. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Radaeva, S., Sun, R., Jaruga, B., Nguyen, V.T., Tian, Z., Gao, B. Gastroenterology (2006) [Pubmed]
  7. Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma). Sun, R., Gao, B. Gastroenterology (2004) [Pubmed]
  8. Potential role of toll-like receptor 3 in a murine model of polyinosinic-polycytidylic acid-induced embryo resorption. Lin, Y., Zeng, Y., Zeng, S., Wang, T. Fertil. Steril. (2006) [Pubmed]
  9. Toll-like receptor 3 ligand-induced antiviral response in mouse osteoblastic cells. Nakamura, K., Deyama, Y., Yoshimura, Y., Suzuki, K., Morita, M. Int. J. Mol. Med. (2007) [Pubmed]
  10. Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages. Jiang, W., Sun, R., Wei, H., Tian, Z. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  11. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Schulz, O., Diebold, S.S., Chen, M., Näslund, T.I., Nolte, M.A., Alexopoulou, L., Azuma, Y.T., Flavell, R.A., Liljeström, P., Reis e Sousa, C. Nature (2005) [Pubmed]
  12. Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. Johnsen, I.B., Nguyen, T.T., Ringdal, M., Tryggestad, A.M., Bakke, O., Lien, E., Espevik, T., Anthonsen, M.W. EMBO J. (2006) [Pubmed]
  13. Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering. Myers, L., Takahashi, C., Mittler, R.S., Rossi, R.J., Vella, A.T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  14. Genetic analysis of the innate immune responses in wild-derived inbred strains of mice. Stephan, K., Smirnova, I., Jacque, B., Poltorak, A. Eur. J. Immunol. (2007) [Pubmed]
  15. Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. Thivierge, M., Stankova, J., Rola-Pleszczynski, M. J. Allergy Clin. Immunol. (2006) [Pubmed]
  16. Requirement of type I interferon signaling for arthritis triggered by double-stranded RNA. Magnusson, M., Zare, F., Tarkowski, A. Arthritis Rheum. (2006) [Pubmed]
  17. Synthetic double-stranded RNA poly(I:C) combined with mucosal vaccine protects against influenza virus infection. Ichinohe, T., Watanabe, I., Ito, S., Fujii, H., Moriyama, M., Tamura, S., Takahashi, H., Sawa, H., Chiba, J., Kurata, T., Sata, T., Hasegawa, H. J. Virol. (2005) [Pubmed]
  18. The rationale for combined chemo/immunotherapy using a Toll-like receptor 3 (TLR3) agonist and tumour-derived exosomes in advanced ovarian cancer. Adams, M., Navabi, H., Croston, D., Coleman, S., Tabi, Z., Clayton, A., Jasani, B., Mason, M.D. Vaccine (2005) [Pubmed]
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