High impact information on UCP2

• However, despite uncoupling, neither UCP1 nor UCP2 altered superoxide formation [1].
• Respiratory uncoupling by UCP1 and UCP2 and superoxide generation in endothelial cell mitochondria [1].
• UCP1 and UCP2 overexpression both increased the proton conductance of endothelial cell mitochondria, as rigorously determined by the kinetic relationship of respiration to inner membrane potential [1].
• First evidence of uncoupling protein-2 (UCP-2) and -3 (UCP-3) gene expression in piglet skeletal muscle and adipose tissue [2].
• Both short- and medium-chain fatty acids inhibited acetyl coenzyme A carboxylase (ACC) activities, which is pivotal in lipid synthesis, but elevated expression of uncoupling protein 2 (UCP2) mRNA, which is important in energy expenditure [3].

Biological context of UCP2

• Neither UCP2 nor leptin gene expression was affected by Cu supplementation [4].

Anatomical context of UCP2

• On d 112 of the finishing period, subcutaneous adipose tissue biopsies were obtained from the tailhead of three animals per treatment and analyzed for ACC, SCD, UCP2, and leptin mRNA expression [4].

Other interactions of UCP2

• Bovine UCP2 and UCP3 map to BTA15 [5].

Analytical, diagnostic and therapeutic context of UCP2

• Using RT-PCR we have successfully cloned a partial UCP2 sequence and a complete UCP3 cDNA [2].

References