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Gene Review

SCD  -  stearoyl-CoA desaturase (delta-9-desaturase)

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Disease relevance of SCD

  • A search of the Mycobacterium tuberculosis genome showed that a previously unidentified gene encodes a fatty-acid desaturase with an N-terminal b(5) domain [1].

High impact information on SCD


Biological context of SCD


Anatomical context of SCD


Associations of SCD with chemical compounds


Physical interactions of SCD


Other interactions of SCD


Analytical, diagnostic and therapeutic context of SCD


  1. Structure and characterization of Ectothiorhodospira vacuolata cytochrome b(558), a prokaryotic homologue of cytochrome b(5). Kostanjevecki, V., Leys, D., Van Driessche, G., Meyer, T.E., Cusanovich, M.A., Fischer, U., Guisez, Y., Van Beeumen, J. J. Biol. Chem. (1999) [Pubmed]
  2. Modulation in delta 9, delta 6, and delta 5 fatty acid desaturase activity in the human intestinal CaCo-2 cell line. Dias, V.C., Parsons, H.G. J. Lipid Res. (1995) [Pubmed]
  3. Properties of rat liver microsomal stearoyl-coenzyme A desaturase. Jeffcoat, R., Brawn, P.R., Safford, R., James, A.T. Biochem. J. (1977) [Pubmed]
  4. The inhibitory effect of trans-10, cis-12 CLA on lipid synthesis in bovine mammary epithelial cells involves reduced proteolytic activation of the transcription factor SREBP-1. Peterson, D.G., Matitashvili, E.A., Bauman, D.E. J. Nutr. (2004) [Pubmed]
  5. Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3'-UTR sequence arising from a single exon. Bernard, L., Leroux, C., Hayes, H., Gautier, M., Chilliard, Y., Martin, P. Gene (2001) [Pubmed]
  6. Differential induction of stearoyl-CoA desaturase and acyl-CoA oxidase genes by fibrates in HepG2 cells. Rodríguez, C., Cabrero, A., Roglans, N., Adzet, T., Sánchez, R.M., Vázquez, M., Ciudad, C.J., Laguna, J.C. Biochem. Pharmacol. (2001) [Pubmed]
  7. Cloning and characterization of bovine stearoyl CoA desaturasel cDNA from adipose tissues. Chung, M., Ha, S., Jeong, S., Bok, J., Cho, K., Baik, M., Choi, Y. Biosci. Biotechnol. Biochem. (2000) [Pubmed]
  8. Genotype of stearoyl-coA desaturase is associated with fatty acid composition in Japanese Black cattle. Taniguchi, M., Utsugi, T., Oyama, K., Mannen, H., Kobayashi, M., Tanabe, Y., Ogino, A., Tsuji, S. Mamm. Genome (2004) [Pubmed]
  9. Postnatal development of stearoyl coenzyme A desaturase gene expression and adiposity in bovine subcutaneous adipose tissue. Martin, G.S., Lunt, D.K., Britain, K.G., Smith, S.B. J. Anim. Sci. (1999) [Pubmed]
  10. A mathematical model for mammary fatty acid synthesis and triglyceride assembly: the role of stearoyl CoA desaturase (SCD). Shorten, P.R., Pleasants, T.B., Upreti, G.C. J. Dairy Res. (2004) [Pubmed]
  11. Influence of bovine growth hormone and growth hormone-releasing factor on messenger RNA abundance of lipoprotein lipase and stearoyl-CoA desaturase in the bovine mammary gland and adipose tissue. Beswick, N.S., Kennelly, J.J. J. Anim. Sci. (2000) [Pubmed]
  12. Effects of dietary copper on the expression of lipogenic genes and metabolic hormones in steers. Lee, S.H., Engle, T.E., Hossner, K.L. J. Anim. Sci. (2002) [Pubmed]
  13. Gene expression profiling of bovine skeletal muscle in response to and during recovery from chronic and severe undernutrition. Lehnert, S.A., Byrne, K.A., Reverter, A., Nattrass, G.S., Greenwood, P.L., Wang, Y.H., Hudson, N.J., Harper, G.S. J. Anim. Sci. (2006) [Pubmed]
  14. Isolation and characterization of the bovine Stearoyl-CoAdesaturase promoter and analysis of polymorphisms in the promoter region in dairy cows. Keating, A.F., Stanton, C., Murphy, J.J., Smith, T.J., Ross, R.P., Cairns, M.T. Mamm. Genome (2005) [Pubmed]
  15. Glycosphingolipid acyl chain order profiles: substituent effects. Morrow, M.R., Singh, D., Grant, C.W. Biochim. Biophys. Acta (1995) [Pubmed]
  16. An in vitro evaluation of the cytotoxicity of various endodontic irrigants on human gingival fibroblasts. Barnhart, B.D., Chuang, A., Lucca, J.J., Roberts, S., Liewehr, F., Joyce, A.P. Journal of endodontics. (2005) [Pubmed]
  17. Fatty acid composition and fatty acid elongase and stearoyl-CoA desaturase activities in tissues of steers fed high oleate sunflower seed. Chang, J.H., Lunt, D.K., Smith, S.B. J. Nutr. (1992) [Pubmed]
  18. Direct desaturation of free myristic acid by hen liver microsomal Delta9-desaturase without prior activation to myristoyl-CoA derivative. Awad, A.C., Shin, H.S., Romsos, D.R., Gray, J.I. J. Agric. Food Chem. (2004) [Pubmed]
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