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BCL2A1  -  BCL2-related protein A1

Homo sapiens

Synonyms: ACC-1, ACC-2, BCL2L5, BFL1, Bcl-2-like protein 5, ...
 
 
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Disease relevance of BCL2A1

 

High impact information on BCL2A1

 

Biological context of BCL2A1

 

Anatomical context of BCL2A1

  • BFL-1 is the smallest member of the BCL-2 family and has been shown to retard apoptosis in various cell lines [6].
  • Thus, the role of BCL2A1-specific T cells in differential induction of GVL reactivity and GVHD may depend on the presence of inflammatory responses that may occur during GVHD [8].
  • Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant [9].
 

Associations of BCL2A1 with chemical compounds

  • Molecular modeling showed that BFL-1 could have a similar core structure as BCL-xL, consisting of seven alpha helices, although both proteins share only the conserved BCL-2 homology domains (BH1 and BH2 domains), but otherwise have very limited sequence homology, particularly in the N-terminal region [6].
  • BAX requires the BH3 domain for interaction with BFL-1 [6].
  • A unique feature of BFL-1 is the presence of a Gln-rich N-terminal region that overlaps with the BH4 domain [7].
  • Elemental analysis of solids with the Hbpa ligand have indicated better complexation for synthesis in toluene, where 74% of the iron atoms were coordinated by the ligand, against 37% for the synthesis in methanol [10].
  • We report the encapsulation of iron and copper metallocomplexes with the ligand (2-hydroxybenzyl)(2-methylpyridyl)amine, Hbpa, and iron complexes with the ligand N,N'-bis(2-hydroxybenzyl)-N,N'-bis(2-methylpyridyl) ethylenediamine, H(2)bbpen [10].
 

Physical interactions of BCL2A1

  • We demonstrated in the yeast two-hybrid system that BFL-1 interacts strongly with human BAX but is not able to form homodimers nor to interact with human BCL-2 or BCL-xL [6].
 

Other interactions of BCL2A1

  • Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells [6].
  • A. phagocytophilum infection also altered the apoptotic program of NB4 cells and resulted in increased transcription of antiapoptotic genes (MCL1 and BFL1) [11].
  • Recently, the HLA-A24-restricted mHag ACC-1 and the HLA-B44-restricted mHag ACC-2 encoded by separate polymorphisms within the BCL2A1 gene were characterized [8].
  • We recently identified a new mHA epitope, termed ACC-1, which is presented by HLA-A*2402 and encoded by BCL2A1, whose expression is restricted to haematopoietic cells including leukaemic cells [9].
  • The FGF-4 gene was truncated by DNA rearrangement with a novel gene named GRS [2].
 

Analytical, diagnostic and therapeutic context of BCL2A1

  • Up-regulated expression in nonhematopoietic tissues of the BCL2A1-derived minor histocompatibility antigens in response to inflammatory cytokines: relevance for allogeneic immunotherapy of leukemia [8].
  • The antiapoptotic gene A1/BFL1 is a WT1 target gene that mediates granulocytic differentiation and resistance to chemotherapy [5].
  • For the immobilization with the H(2)bbpen ligand in toluene it was observed that 46% of the iron atoms are coordinated, showing that the diffusion of the small ligand Hbpa through the zeolite cage was facilitated [10].

References

  1. Abnormal expression of apoptosis-related genes in haematological malignancies: overexpression of MYC is poor prognostic sign in mantle cell lymphoma. Nagy, B., Lundán, T., Larramendy, M.L., Aalto, Y., Zhu, Y., Niini, T., Edgren, H., Ferrer, A., Vilpo, J., Elonen, E., Vettenranta, K., Franssila, K., Knuutila, S. Br. J. Haematol. (2003) [Pubmed]
  2. GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes. Kenny, J.J., Knobloch, T.J., Augustus, M., Carter, K.C., Rosen, C.A., Lang, J.C. Oncogene (1997) [Pubmed]
  3. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. Mandal, M., Borowski, C., Palomero, T., Ferrando, A.A., Oberdoerffer, P., Meng, F., Ruiz-Vela, A., Ciofani, M., Zuniga-Pflucker, J.C., Screpanti, I., Look, A.T., Korsmeyer, S.J., Rajewsky, K., von Boehmer, H., Aifantis, I. J. Exp. Med. (2005) [Pubmed]
  4. Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens. Akatsuka, Y., Nishida, T., Kondo, E., Miyazaki, M., Taji, H., Iida, H., Tsujimura, K., Yazaki, M., Naoe, T., Morishima, Y., Kodera, Y., Kuzushima, K., Takahashi, T. J. Exp. Med. (2003) [Pubmed]
  5. The antiapoptotic gene A1/BFL1 is a WT1 target gene that mediates granulocytic differentiation and resistance to chemotherapy. Simpson, L.A., Burwell, E.A., Thompson, K.A., Shahnaz, S., Chen, A.R., Loeb, D.M. Blood (2006) [Pubmed]
  6. Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells. Zhang, H., Cowan-Jacob, S.W., Simonen, M., Greenhalf, W., Heim, J., Meyhack, B. J. Biol. Chem. (2000) [Pubmed]
  7. Functional dissection of Bfl-1, a Bcl-2 homolog: anti-apoptosis, oncogene-cooperation and cell proliferation activities. D'Sa-Eipper, C., Chinnadurai, G. Oncogene (1998) [Pubmed]
  8. Up-regulated expression in nonhematopoietic tissues of the BCL2A1-derived minor histocompatibility antigens in response to inflammatory cytokines: relevance for allogeneic immunotherapy of leukemia. Kloosterboer, F.M., van Luxemburg-Heijs, S.A., van Soest, R.A., van Egmond, H.M., Willemze, R., Falkenburg, J.H. Blood (2005) [Pubmed]
  9. Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant. Nishida, T., Akatsuka, Y., Morishima, Y., Hamajima, N., Tsujimura, K., Kuzushima, K., Kodera, Y., Takahashi, T. Br. J. Haematol. (2004) [Pubmed]
  10. Encapsulation of Fe(III) and Cu(II) complexes in NaY zeolite. Drechsel, S.M., Kaminski, R.C., Nakagaki, S., Wypych, F. Journal of colloid and interface science. (2004) [Pubmed]
  11. Modulation of NB4 promyelocytic leukemic cell machinery by Anaplasma phagocytophilum. Pedra, J.H., Sukumaran, B., Carlyon, J.A., Berliner, N., Fikrig, E. Genomics (2005) [Pubmed]
 
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