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Gene Review

SLC2A2  -  solute carrier family 2 (facilitated...

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High impact information on SLC2A2

  • Expression of mRNAs for the insulin-sensitive muscle/adipose transporter (GLUT-4), brain/fetal skeletal muscle transporter (GLUT-3), or the hepatic transporter (GLUT-2) were not detected in either control or treated cells [1].
  • Glut2 expression was restricted to the period of blastocyst elongation at d14 and d16 [2].
  • Treatment of fetal and adult pancreatic islets with 1 microg/ml bGH did not alter the expression of GLUT-2 mRNAs, but significantly increased GLUT-2 protein levels in adult islets by 50% [3].
  • Taken as a whole, these findings suggest that 1-deoxy-1-[125I]iodo-D-mannoheptulose does not display the same specificity towards GLUT2, as that previously documented in the case of D-[3H]- mannoheptulose [4].
  • GLUT 1 mRNA quantity decreased whereas GLUT 2 increased with age [5].

Anatomical context of SLC2A2


  1. Regulation of hexose transport in aortic endothelial cells by vascular permeability factor and tumor necrosis factor-alpha, but not by insulin. Pekala, P., Marlow, M., Heuvelman, D., Connolly, D. J. Biol. Chem. (1990) [Pubmed]
  2. Glucose transporter expression is developmentally regulated in in vitro derived bovine preimplantation embryos. Augustin, R., Pocar, P., Navarrete-Santos, A., Wrenzycki, C., Gandolfi, F., Niemann, H., Fischer, B. Mol. Reprod. Dev. (2001) [Pubmed]
  3. Effects of triiodothyronine and bovine growth hormone on glucose transporter isoform-2 (GLUT-2) and glucokinase (GK) gene expression in pancreatic islets of fetal and adult rats. García-Flores, M., Blázquez, E., Zueco, J.A. Pflugers Arch. (2001) [Pubmed]
  4. Uptake of 1-deoxy-1-[125I]iodo-D-mannoheptulose by different cell types: in vitro and in vivo experiments. Sener, A., Bessieres, B., Courtois, P., Ladriere, L., Louchami, K., Jijakli, H., Malaisse, W.J. Int. J. Mol. Med. (2001) [Pubmed]
  5. Measurement of GLUT mRNA in liver of fetal and neonatal rats using a novel method of quantitative polymerase chain reaction. Lane, R.H., Flozak, A.S., Simmons, R.A. Biochem. Mol. Med. (1996) [Pubmed]
  6. Insulin, insulin-like growth factors and glucose transporters: temporal patterns of gene expression in early murine and bovine embryos. Schultz, G.A., Hogan, A., Watson, A.J., Smith, R.M., Heyner, S. Reprod. Fertil. Dev. (1992) [Pubmed]
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