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Gene Review

Slc2a2  -  solute carrier family 2 (facilitated...

Rattus norvegicus

Synonyms: GLUT-2, GTT2, Glucose transporter type 2, liver, Glut-2, Glut2, ...
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Disease relevance of Slc2a2

  • In contrast, IUGR failed to alter the 2-fold increase in extrauterine Glut 2 concentrations (1-7-d postnatal animals), the isoform found in fetal and postnatal hepatocytic cell membranes [1].
  • We find that in addition to insulin the insulinoma express the normal beta-cell markers Pdx-1, IAPP, and Glut-2, and that these markers are absent from the glucagonoma: a reflection of the normal alpha-cell [2].
  • In rats bearing sarcoma, the staining intensity was significantly decreased, suggesting that Glut 2 with its bi-directional transport capacity was down-regulated in the tumour-bearing state [3].

High impact information on Slc2a2


Chemical compound and disease context of Slc2a2

  • Employing immunohistochemical and Western blot analyses, we investigated the cellular localization (22-d fetal and 14-d postnatal animals) and concentrations (22-d fetal to 21-d postnatal animals) of rat hepatic glucose transporters (Glut 1 and Glut 2) and glucokinase in response to development and uteroplacental insufficiency with IUGR [1].

Biological context of Slc2a2


Anatomical context of Slc2a2

  • We have identified a 70-kDa cytosolic protein (GTBP70) in rat adipocytes that binds to glutathione S-transferase fusion proteins corresponding to the cytoplasmic domains of the facilitative glucose transporter isoforms Glut1, Glut2, and Glut4 [11].
  • Glut 2 expression in abdominal testis was increased (45%, 67%, and 40% at 10, 20 and 30 days, respectively) but no significant change was observed in contralateral scrotal testis [12].
  • Glut 2 immunoreactivity was uniformly seen in the cellular membrane of hepatocytes from control animals [3].
  • In both hypothalamus and brainstem, gene expression of Glut-2, GK, and Glp-1R was significantly lower in refed rats compared with food-restricted rats [10].

Associations of Slc2a2 with chemical compounds

  • Here we show that exposure of isolated rat pancreatic islets to palmitic acid induced a approximately 70% decrease in IDX-1 mRNA and protein expression as well as 40 and 65% decreases in the binding activity of IDX-1 for its cognate cis-regulatory elements of the Glut2 and insulin promoters, respectively [8].

Other interactions of Slc2a2

  • We conclude that hepatic Glut 1 concentrations reflect the extramedullary hematopoietic cellular mass, whereas extrauterine Glut 2 changes herald the need for enhanced flexibility in hepatocytic glucose transport with the initiation of food ingestion [1].
  • This, together with NF-kappa B-dependent inhibition of Glut-2, pro-hormone convertase-1, and Isl-1 expression, probably contributes to the loss of differentiated beta-cell functions [13].
  • To elucidate interactions between the glucose transport system and hepatic glucose production in the tumour-bearing state, glycogen storage, expression of glucose transporter isoform 2 (Glut 2) and activities of glucose-6-phosphatase (G-6-Pase) and hexokinase were histochemically examined in hepatocytes of tumour-bearing rats [3].

Analytical, diagnostic and therapeutic context of Slc2a2

  • Immunoblotting of testis proteins with Glut transporter antibodies revealed only the presence of Glut 2 and 3 proteins [12].
  • We used quantitative real-time RT-PCR to measure changes in hypothalamic and brainstem Glut-2, GK, and Glp-1R expression of these genes induced by food restriction and refeeding [10].


  1. The effect of intrauterine growth restriction upon fetal and postnatal hepatic glucose transporter and glucokinase proteins. Sadiq, H.F., deMello, D.E., Devaskar, S.U. Pediatr. Res. (1998) [Pubmed]
  2. mRNA profiling of rat islet tumors reveals nkx 6.1 as a beta-cell-specific homeodomain transcription factor. Jensen, J., Serup, P., Karlsen, C., Nielsen, T.F., Madsen, O.D. J. Biol. Chem. (1996) [Pubmed]
  3. Alteration in immunoexpression of glucose transporter 2 in liver of tumour-bearing rats. Doi, C., Noguchi, Y., Ito, T., Yoshikawa, T., Makino, T., Matsumoto, A. International journal of experimental pathology. (1998) [Pubmed]
  4. The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells. Heimberg, H., De Vos, A., Moens, K., Quartier, E., Bouwens, L., Pipeleers, D., Van Schaftingen, E., Madsen, O., Schuit, F. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Beta cells arise from glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreas. Pang, K., Mukonoweshuro, C., Wong, G.G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  6. Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development. Miralles, F., Czernichow, P., Scharfmann, R. Development (1998) [Pubmed]
  7. Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression. Kohl, C., Ravel, D., Girard, J., Pégorier, J.P. Diabetes (2002) [Pubmed]
  8. Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels. Gremlich, S., Bonny, C., Waeber, G., Thorens, B. J. Biol. Chem. (1997) [Pubmed]
  9. Identification of a novel rat hepatic gene induced early by insulin, independently of glucose. Coffy, S., Decaux, J.F., Girard, J., de Keyzer, Y., Asfari, M. Biochem. J. (2005) [Pubmed]
  10. Short-term food restriction and refeeding alter expression of genes likely involved in brain glucosensing. Zhou, J., Roane, D.S., Xi, X., Bogacka, I., Li, B., Ryan, D.H., Martin, R.J. Exp. Biol. Med. (Maywood) (2003) [Pubmed]
  11. ATP-sensitive binding of a 70-kDa cytosolic protein to the glucose transporter in rat adipocytes. Liu, H., Xiong, S., Shi, Y., Samuel, S.J., Lachaal, M., Jung, C.Y. J. Biol. Chem. (1995) [Pubmed]
  12. Degenerative changes in spermatogonia are associated with loss of glucose transporter (Glut 3) in abdominal testis of surgically induced unilateral cryptorchidism in rats. Farooqui, S.M., Al-Bagdadi, F., O'Donnell, J.M., Stout, R. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  13. A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells. Cardozo, A.K., Heimberg, H., Heremans, Y., Leeman, R., Kutlu, B., Kruhøffer, M., Ørntoft, T., Eizirik, D.L. J. Biol. Chem. (2001) [Pubmed]
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