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Gene Review

Slc2a2  -  solute carrier family 2 (facilitated...

Mus musculus

Synonyms: AI266973, GLUT-2, Glucose transporter type 2, liver, Glut-2, Glut2, ...
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High impact information on Slc2a2

  • Pancreatic beta cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response to dietary intake [1].
  • Loss of GlcNAcT-IVa, or the addition of glycan-ligand mimetics, attenuates Glut-2 cell-surface half-life, provoking endocytosis with redistribution into endosomes and lysosomes [1].
  • Remarkably, the induction of diabetes by chronic ingestion of a high-fat diet is associated with reduced GlcNAcT-IV expression and attenuated Glut-2 glycosylation coincident with Glut-2 endocytosis [1].
  • We show that the murine GlcNAcT-IVa glycosyltransferase is required for Glut-2 residency on the beta cell surface by constructing a cell-type- and glycoprotein-specific N-glycan ligand for pancreatic lectin receptors [1].
  • Here we show that homozygous, but not heterozygous, mice deficient in Glut-2 are hyperglycaemic and relatively hypo-insulinaemic and have elevated plasma levels of glucagon, free fatty acids and beta-hydroxybutyrate [2].

Biological context of Slc2a2


Anatomical context of Slc2a2


Associations of Slc2a2 with chemical compounds

  • In beta-cells, Glut-2 has been proposed to be active in the control of glucose-stimulated insulin secretion (GSIS; ref. 2), and its expression is strongly reduced in glucose-unresponsive islets from different animal models of diabetes [2].
  • The polymorphism at threonine 110 had no effect on the expression of Glut2 protein or the uptake of 2-deoxyglucose [7].
  • The lack of any strain differences in 3-O-methyl glucose transport, Glut2 levels and medium nitrite accumulation suggested that STZ transport and nitric oxide metabolism were not responsible for differences in STZ sensitivity and metabolite accumulation [8].
  • We examined them morphologically and measured islet NAD + NADH content, streptozotocin metabolite accumulation, glucose transport capacity, Glut2 levels and medium nitrite accumulation [8].
  • The role of Glut2 can be to enhance the depletion of gluconeogenic cells into glucose-6-phosphate (G6-P) when cultivated without glucose [9].

Other interactions of Slc2a2

  • Altered Glut-2 accumulation and beta-cell function in mice lacking the exocrine-specific transcription factor, Mist1 [10].
  • One expressed the glucose transporter-2 (Glut-2), and the other cell type coexpressed insulin and somatostatin [11].
  • Development of these congenic strains has allowed Idd3 to be localized between Glut2 and D3Mit6, close to the Il2 locus [12].
  • Down-regulation of SREBP-1 expression with the specific small interfering RNA blocked basal and LXRbeta-induced expression of pancreatic duodenal homeobox 1 (PDX-1), insulin, and Glut2 genes [13].
  • Further analysis revealed that insulin 1, insulin 2, Pdx1, Beta2, and Glut-2 transcripts are diminished in MafA-deficient mice [14].

Analytical, diagnostic and therapeutic context of Slc2a2

  • Chromatin immunoprecipitation using anti-HNF6 antibodies was performed on chromatin isolated from Foxa2(loxP/loxP) Alfp.Cre and control mouse livers, and HNF6 binding to its target, Glut2, was determined by quantitative PCR [15].
  • Real-time quantitative RT-PCR analysis of islets from Anx7 heterozygous mice and littermate controls revealed remarkable down-regulation in PTEN, Glut-2, PDX-1, IGF-1, and Neuro D1 expression, but not in liver [16].
  • In vitro, splenocytes from IFA treated animals showed non-specific immunosuppression with ConA (p < 0.01), whereas the response to 1-casein and Glut-2 was raised in IFA treated animals with respect to controls [17].


  1. Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Ohtsubo, K., Takamatsu, S., Minowa, M.T., Yoshida, A., Takeuchi, M., Marth, J.D. Cell (2005) [Pubmed]
  2. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Guillam, M.T., Hümmler, E., Schaerer, E., Yeh, J.I., Birnbaum, M.J., Beermann, F., Schmidt, A., Dériaz, N., Thorens, B., Wu, J.Y. Nat. Genet. (1997) [Pubmed]
  3. Characterizations of candidate genes for IDD susceptibility from the diabetes-prone NOD mouse strain. Chesnut, K., She, J.X., Cheng, I., Muralidharan, K., Wakeland, E.K. Mamm. Genome (1993) [Pubmed]
  4. The nucleotide sequence of cDNA for a mouse liver-type glucose transporter protein. Asano, T., Shibasaki, Y., Lin, J.L., Akanuma, Y., Takaku, F., Oka, Y. Nucleic Acids Res. (1989) [Pubmed]
  5. Pancreatic-specific expression of the glucose transporter type 2 gene: identification of cis-elements and islet-specific trans-acting factors. Bonny, C., Thompson, N., Nicod, P., Waeber, G. Mol. Endocrinol. (1995) [Pubmed]
  6. Cloning and characterization of rat pancreatic beta-cell/liver type glucose transporter gene: a unique exon/intron organization. Ahn, Y.H., Kim, J.W., Han, G.S., Lee, B.G., Kim, Y.S. Arch. Biochem. Biophys. (1995) [Pubmed]
  7. A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity. Mueckler, M., Kruse, M., Strube, M., Riggs, A.C., Chiu, K.C., Permutt, M.A. J. Biol. Chem. (1994) [Pubmed]
  8. Differential metabolite accumulation may be the cause of strain differences in sensitivity to streptozotocin-induced beta cell death in inbred mice. Cardinal, J.W., Allan, D.J., Cameron, D.P. Endocrinology (1998) [Pubmed]
  9. Transcriptional regulation by glucose in the liver. Kahn, A. Biochimie (1997) [Pubmed]
  10. Altered Glut-2 accumulation and beta-cell function in mice lacking the exocrine-specific transcription factor, Mist1. Fazio, E.N., Everest, M., Colman, R., Wang, R., Pin, C.L. J. Endocrinol. (2005) [Pubmed]
  11. Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Guz, Y., Nasir, I., Teitelman, G. Endocrinology (2001) [Pubmed]
  12. Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes. Wicker, L.S., Todd, J.A., Prins, J.B., Podolin, P.L., Renjilian, R.J., Peterson, L.B. J. Exp. Med. (1994) [Pubmed]
  13. Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels. Zitzer, H., Wente, W., Brenner, M.B., Sewing, S., Buschard, K., Gromada, J., Efanov, A.M. Endocrinology (2006) [Pubmed]
  14. MafA is a key regulator of glucose-stimulated insulin secretion. Zhang, C., Moriguchi, T., Kajihara, M., Esaki, R., Harada, A., Shimohata, H., Oishi, H., Hamada, M., Morito, N., Hasegawa, K., Kudo, T., Engel, J.D., Yamamoto, M., Takahashi, S. Mol. Cell. Biol. (2005) [Pubmed]
  15. Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2. Rubins, N.E., Friedman, J.R., Le, P.P., Zhang, L., Brestelli, J., Kaestner, K.H. Mol. Cell. Biol. (2005) [Pubmed]
  16. Anx7 is required for nutritional control of gene expression in mouse pancreatic islets of Langerhans. Srivastava, M., Eidelman, O., Leighton, X., Glasman, M., Goping, G., Pollard, H.B. Mol. Med. (2002) [Pubmed]
  17. Incomplete Freund's adjuvant reduces diabetes in the non-obese diabetic mouse. Liddi, R., Beales, P.E., Rosignoli, G., Pozzilli, P. Horm. Metab. Res. (2000) [Pubmed]
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