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Gene Review

SLC2A2  -  solute carrier family 2 (facilitated...

Gallus gallus

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High impact information on SLC2A2

  • These effects involve both apical (SGLT1) and basolateral (GLUT2) hexose transporters [1].
  • The binding of phlorizin to BBMV and cytochalasin B to BLMV were used as indicators of the abundance of SGLT1 and GLUT2, respectively [1].
  • Glucose transporter 2 (GLUT2) is a major transporter that is expressed strongly in hepatocytes [2].
  • AG-1478 (an EGF receptor antagonist) and genistein and herbimycin A (tyrosine kinase inhibitors) blocked the EGF-induced decrease in [(3)H]deoxyglucose uptake, which correlated with the GLUT2 expression level [2].
  • The Glut2 transporter inhibitors phloretin and cytochalasin B added following 30-min mannose uptake reduced the previously accumulated D-mannose, whereas these two agents increased the cell to external medium 3-O-methyl-glucose (3-OMG) concentration ratio [3].

Biological context of SLC2A2

  • Within the predicted amino acid sequence, there are 12 putative transmembrane helices with a relatively large exofacial hydrophilic loop between transmembrane segments 1 and 2, which is characteristic of mammalian GLUT 2 [4].
  • We have now studied the effect of resalination of low-Na+ adapted chickens on glucose kinetics across SGLT1 (using -methyl-D-glucoside as substrate) and GLUT2 (using D-glucose) and on the specific binding of phlorizin and cytochalasin B, respectively [5].
  • In chickens, we have shown that intestinal absorption of glucose via apical SGLT1 and basolateral GLUT2 transport systems is affected by dietary Na+; low-Na+ adapted birds show a dramatic reduction of glucose transporters in both membranes in the rectum, an intermediate response in the ileum and no effects in the jejunum [5].

Anatomical context of SLC2A2

  • Therefore, this study examined the effect of EGF on GLUT2 and its related signal cascades in primary cultured chicken hepatocytes [2].
  • The good correlation between the -methyl-D-glucoside and D-glucose Vmax and the SGLT1 and GLUT2 density, respectively, supports the view that the increase in apical and basolateral hexose transport found in the ileum and rectum of both groups of resalinated birds is due to an increase in the number of protein transporters [5].

Associations of SLC2A2 with chemical compounds

  • In our analysis of glucose transporter (GLUT) isoform expression, the level of GLUT1 mRNA increased with follicle development while GLUT2, GLUT3 and GLUT8 mRNA levels were unaffected by follicle development [6].

Other interactions of SLC2A2

  • The aim of this study was to identify the extent of mRNA expression of GLUT1, GLUT2, GLUT3 and GLUT8 in chickens intrinsically lacking GLUT4 [7].

Analytical, diagnostic and therapeutic context of SLC2A2


  1. Aldosterone mediates the changes in hexose transport induced by low sodium intake in chicken distal intestine. Garriga, C., Planas, J.M., Moretó, M. J. Physiol. (Lond.) (2001) [Pubmed]
  2. EGF-induced inhibition of glucose transport is mediated by PKC and MAPK signal pathways in primary cultured chicken hepatocytes. Lee, M.Y., Park, S.H., Lee, Y.J., Heo, J.S., Lee, J.H., Han, H.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  3. D-mannose transport and metabolism in isolated enterocytes. Durán, J.M., Cano, M., Peral, M.J., Ilundáin, A.A. Glycobiology (2004) [Pubmed]
  4. Identification of chicken liver glucose transporter. Wang, M.Y., Tsai, M.Y., Wang, C. Arch. Biochem. Biophys. (1994) [Pubmed]
  5. Effects of resalination on intestinal glucose transport in chickens adapted to low Na+ intakes. Garriga, C., Moretó, M., Planas, J.M. Exp. Physiol. (2000) [Pubmed]
  6. Changes in gene expression involved in energy utilization during chicken follicle development. Seol, H.S., Sato, K., Murakami, H., Toyomizu, M., Akiba, Y. Anim. Reprod. Sci. (2006) [Pubmed]
  7. Characterisation of glucose transporter (GLUT) gene expression in broiler chickens. Kono, T., Nishida, M., Nishiki, Y., Seki, Y., Sato, K., Akiba, Y. Br. Poult. Sci. (2005) [Pubmed]
  8. Regulation of glucose transporters during development of the retinal pigment epithelium. Ban, Y., Rizzolo, L.J. Brain Res. Dev. Brain Res. (2000) [Pubmed]
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