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STAT5A  -  signal transducer and activator of...

Bos taurus

Synonyms: STAT5A/MGF, STATA5
 
 
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High impact information on STAT5A

 

Biological context of STAT5A

  • With reverse transcription-PCR (RT-PCR) and other means we showed that the STAT5A expression level in the liver was higher in cattle with AA than GG genotype [5].
  • Using PCR-heteroduplex and sequencing we identified A/G substitution at position -488 in the promoter region of the bovine STAT5A gene [5].
  • The STAT5A gene is a potential quantitative trait locus (QTL) and genetic marker of production traits in dairy cattle [4].
  • New SSCP polymorphism within bovine STAT5A gene and its associations with milk performance traits in Black-and-White and Jersey cattle [4].
 

Other interactions of STAT5A

  • STAT5A, previously known as MGF, transduces prolactin signals to the milk protein genes [6].
 

Analytical, diagnostic and therapeutic context of STAT5A

  • Electrophoretic mobility shift assay (EMSA) showed that the A-->G transition at position -488 increased the STAT5A gene promoter binding capacity for liver nuclear proteins [possibly hepatic nuclear factor (HNF)-3] [5].
  • Ten PCR fragments representing most important functional domains of STAT5A were screened for polymorphism [4].

References

  1. STAT5 binding contributes to lactational stimulation of promoter III expressing the bovine acetyl-CoA carboxylase alpha-encoding gene in the mammary gland. Mao, J., Molenaar, A.J., Wheeler, T.T., Seyfert, H.M. J. Mol. Endocrinol. (2002) [Pubmed]
  2. STAT5A encoding gene maps to chromosome 19 in cattle and goat and to chromosome 11 in sheep. Goldammer, T., Meyer, L., Seyfert, H.M., Brunner, R.M., Schwerin, M. Mamm. Genome (1997) [Pubmed]
  3. Nucleotide sequence variation in the transcription factor STAT5A 5'-noncoding region in Bos taurus and Bos indicus cattle. Flisikowski, K., Hiendleder, S., Zwierzchowski, L. Biochem. Genet. (2005) [Pubmed]
  4. New SSCP polymorphism within bovine STAT5A gene and its associations with milk performance traits in Black-and-White and Jersey cattle. Brym, P., Kamiński, S., Ruść, A. J. Appl. Genet. (2004) [Pubmed]
  5. Promoter variant-dependent expression of the STAT5A gene in bovine liver. Flisikowski, K., Starzyński, R.R., Zwierzchowski, L. Biochim. Biophys. Acta (2004) [Pubmed]
  6. The DNA-binding capacity of genetic variants of the bovine STAT5A transcription factor. Flisikowski, K., Szymanowska, M., Zwierzchowski, L. Cell. Mol. Biol. Lett. (2003) [Pubmed]
 
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