The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

STAT5A  -  signal transducer and activator of...

Bos taurus

Synonyms: STAT5A/MGF, STATA5
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on STAT5A


Biological context of STAT5A

  • With reverse transcription-PCR (RT-PCR) and other means we showed that the STAT5A expression level in the liver was higher in cattle with AA than GG genotype [5].
  • Using PCR-heteroduplex and sequencing we identified A/G substitution at position -488 in the promoter region of the bovine STAT5A gene [5].
  • The STAT5A gene is a potential quantitative trait locus (QTL) and genetic marker of production traits in dairy cattle [4].
  • New SSCP polymorphism within bovine STAT5A gene and its associations with milk performance traits in Black-and-White and Jersey cattle [4].

Other interactions of STAT5A

  • STAT5A, previously known as MGF, transduces prolactin signals to the milk protein genes [6].

Analytical, diagnostic and therapeutic context of STAT5A

  • Electrophoretic mobility shift assay (EMSA) showed that the A-->G transition at position -488 increased the STAT5A gene promoter binding capacity for liver nuclear proteins [possibly hepatic nuclear factor (HNF)-3] [5].
  • Ten PCR fragments representing most important functional domains of STAT5A were screened for polymorphism [4].


  1. STAT5 binding contributes to lactational stimulation of promoter III expressing the bovine acetyl-CoA carboxylase alpha-encoding gene in the mammary gland. Mao, J., Molenaar, A.J., Wheeler, T.T., Seyfert, H.M. J. Mol. Endocrinol. (2002) [Pubmed]
  2. STAT5A encoding gene maps to chromosome 19 in cattle and goat and to chromosome 11 in sheep. Goldammer, T., Meyer, L., Seyfert, H.M., Brunner, R.M., Schwerin, M. Mamm. Genome (1997) [Pubmed]
  3. Nucleotide sequence variation in the transcription factor STAT5A 5'-noncoding region in Bos taurus and Bos indicus cattle. Flisikowski, K., Hiendleder, S., Zwierzchowski, L. Biochem. Genet. (2005) [Pubmed]
  4. New SSCP polymorphism within bovine STAT5A gene and its associations with milk performance traits in Black-and-White and Jersey cattle. Brym, P., Kamiński, S., Ruść, A. J. Appl. Genet. (2004) [Pubmed]
  5. Promoter variant-dependent expression of the STAT5A gene in bovine liver. Flisikowski, K., Starzyński, R.R., Zwierzchowski, L. Biochim. Biophys. Acta (2004) [Pubmed]
  6. The DNA-binding capacity of genetic variants of the bovine STAT5A transcription factor. Flisikowski, K., Szymanowska, M., Zwierzchowski, L. Cell. Mol. Biol. Lett. (2003) [Pubmed]
WikiGenes - Universities