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Gene Review

Stat5a  -  signal transducer and activator of...

Rattus norvegicus

Synonyms: Mammary gland factor, Mgf, Signal transducer and activator of transcription 5A
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Disease relevance of Stat5a

  • High Stat5a nuclear expression was closely correlated with the higher-grade carcinomas [1].
  • Stat5a nuclear expression was also detected in intraductal proliferations (10 of 21 lesions) and in ductal carcinomas in situ (13 of 15 lesions) [1].
  • Stat5a nuclear expression was detected in ductal and lobular carcinomas and DCIS at a frequency of 48% (15/31), 33% (2/6), and 40% (2/5), respectively [1].

High impact information on Stat5a


Chemical compound and disease context of Stat5a


Biological context of Stat5a


Anatomical context of Stat5a

  • Surprisingly, Stat5a mRNA and protein were readily detected both in virgin rats and after mammary gland involution [6].
  • A polyclonal antibody to a carboxy-terminal peptide of Stat5a1 was generated and used to measure the level of this isoform during mammary gland development and after PRL induction in COS cells transiently transfected with Stat5a and the long form of the PRL receptor [6].

Other interactions of Stat5a

  • Through mutational analysis, a single nucleotide difference between the ERalpha and ERbeta Stat5 response elements was shown to be responsible for the lack of Stat5a-mediated stimulation of ERbeta [8].

Analytical, diagnostic and therapeutic context of Stat5a


  1. Possible role of Stat5a in rat mammary gland carcinogenesis. Shan, L., Yu, M., Clark, B.D., Snyderwine, E.G. Breast Cancer Res. Treat. (2004) [Pubmed]
  2. Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes. Gilmour, K.C., Pine, R., Reich, N.C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Yin-yang 1 and glucocorticoid receptor participate in the Stat5-mediated growth hormone response of the serine protease inhibitor 2.1 gene. Bergad, P.L., Towle, H.C., Berry, S.A. J. Biol. Chem. (2000) [Pubmed]
  4. Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase. Kirken, R.A., Malabarba, M.G., Xu, J., DaSilva, L., Erwin, R.A., Liu, X., Hennighausen, L., Rui, H., Farrar, W.L. J. Biol. Chem. (1997) [Pubmed]
  5. CCAAT/enhancer-binding protein isoforms beta and delta are expressed in mammary epithelial cells and bind to multiple sites in the beta-casein gene promoter. Doppler, W., Welte, T., Philipp, S. J. Biol. Chem. (1995) [Pubmed]
  6. Regulation of mammary gland factor/Stat5a during mammary gland development. Kazansky, A.V., Raught, B., Lindsey, S.M., Wang, Y.F., Rosen, J.M. Mol. Endocrinol. (1995) [Pubmed]
  7. Cloning and chromosomal localization of the rat Stat5 and Yy1 genes. Chen, K.S., Paladugu, A., Aldaz, C.M., Gould, M.N. Cytogenet. Cell Genet. (1996) [Pubmed]
  8. Differential roles for signal transducers and activators of transcription 5a and 5b in PRL stimulation of ERalpha and ERbeta transcription. Frasor, J., Park, K., Byers, M., Telleria, C., Kitamura, T., Yu-Lee, L.Y., Djiane, J., Park-Sarge, O.K., Gibori, G. Mol. Endocrinol. (2001) [Pubmed]
  9. Estradiol represses prolactin-induced expression of Na+/taurocholate cotransporting polypeptide in liver cells through estrogen receptor-alpha and signal transducers and activators of transcription 5a. Cao, J., Wood, M., Liu, Y., Hoffman, T., Hyde, J., Park-Sarge, O.K., Vore, M. Endocrinology (2004) [Pubmed]
  10. PRL signal transduction in the epithelial compartment of rat prostate maintained as long-term organ cultures in vitro. Ahonen, T.J., Härkönen, P.L., Rui, H., Nevalainen, M.T. Endocrinology (2002) [Pubmed]
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