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Gene Review:

CD163L1 - CD163 molecule-like 1

Homo sapiens

Synonyms: CD163 antigen-like 1, CD163B, M160, Scavenger receptor cysteine-rich type 1 protein M160, UNQ6434/PRO23202

Gronlund, J. et al., Yu, K. et al., Stover, C.M. et al., Bang, M.L. et al.

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Disease relevance of CD163L1

Results obtained using ONOO- killing assay revealed that while avirulent mycobacteria including BCG and M. smegmatis are susceptible to this NO-derived oxidant, the virulent Erdman strain of M. tuberculosis and M. bovis, as well as the clinical tuberculous isolate M160, are remarkably resistant [1].

High impact information on CD163L1

RT-PCR analyses showed M160 to be expressed by alveolar macrophages and by the monocyte cell lines HL60, U937, and THP1, but not by Jurkat or Raji cells [2].
Cloning of a novel scavenger receptor cysteine-rich type I transmembrane molecule (M160) expressed by human macrophages [2].
M160-alpha contains three possible phosphorylation sites, which are lost in the alternatively spliced form [2].
Stimulation of U937 cells with phorbol ester resulted in an increased expression of M160 from day 5 onward [2].
We conclude that M160 is a new member of the scavenger receptor cysteine-rich superfamily expressed by the monocyte/macrophage cell lineage [2].

Biological context of CD163L1

Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis [3].

Associations of CD163L1 with chemical compounds

This identified that the nebulin modules M160 to M170 interact with desmin [4].

Analytical, diagnostic and therapeutic context of CD163L1

RT-PCR analysis of 19 different human tissues showed signals for M160-alpha of varying intensity in all tissues, whereas M160-ss was confined to the spleen [2].

References

Toxicity of nitrogen oxides and related oxidants on mycobacteria: M. tuberculosis is resistant to peroxynitrite anion. Yu, K., Mitchell, C., Xing, Y., Magliozzo, R.S., Bloom, B.R., Chan, J. Tuber. Lung Dis. (1999) [Pubmed]
Cloning of a novel scavenger receptor cysteine-rich type I transmembrane molecule (M160) expressed by human macrophages. Gronlund, J., Vitved, L., Lausen, M., Skjodt, K., Holmskov, U. J. Immunol. (2000) [Pubmed]
Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis. Stover, C.M., Schleypen, J., Grønlund, J., Speicher, M.R., Schwaeble, W.J., Holmskov, U. Cytogenet. Cell Genet. (2000) [Pubmed]
Molecular dissection of the interaction of desmin with the C-terminal region of nebulin. Bang, M.L., Gregorio, C., Labeit, S. J. Struct. Biol. (2002) [Pubmed]

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