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Gene Review

GPX4  -  glutathione peroxidase 4

Bos taurus

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High impact information on GPX4


Associations of GPX4 with chemical compounds

  • In the current study, we analyzed the expression of the phospholipid hydroperoxide glutathione peroxidase (PHGPx or GPx-4), a selenoenzyme that directly reduces membrane-bound lipid hydroperoxides in the bovine oviduct [1].

Analytical, diagnostic and therapeutic context of GPX4

  • Interestingly, real-time quantitative RT-PCR analysis showed that GPx-4 expression was highest during the follicular and postovulatory phases [1].


  1. Estrogen selectively up-regulates the phospholipid hydroperoxide glutathione peroxidase in the oviducts. Lapointe, J., Kimmins, S., Maclaren, L.A., Bilodeau, J.F. Endocrinology (2005) [Pubmed]
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