Gene Review:
GPX4 - glutathione peroxidase 4
Bos taurus
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High impact information on GPX4
- This work clearly demonstrates that GPx-4 gene expression is influenced by the proximity of the dominant follicle in the oviduct in vivo [1].
- Using in situ hybridization, we demonstrated that GPx-4 expression is almost restricted to the oviductal luminal epithelium in contrast to GPx-1, which is widely distributed, and GPx-2 and -3, which are mainly detected in the epithelial cells and lamina propria [1].
- Based on intrauterine infusion of estradiol, we determined that the increase in expression and activity of GPx-4 is estrogen mediated [1].
Associations of GPX4 with chemical compounds
- In the current study, we analyzed the expression of the phospholipid hydroperoxide glutathione peroxidase (PHGPx or GPx-4), a selenoenzyme that directly reduces membrane-bound lipid hydroperoxides in the bovine oviduct [1].
Analytical, diagnostic and therapeutic context of GPX4
- Interestingly, real-time quantitative RT-PCR analysis showed that GPx-4 expression was highest during the follicular and postovulatory phases [1].
References
- Estrogen selectively up-regulates the phospholipid hydroperoxide glutathione peroxidase in the oviducts. Lapointe, J., Kimmins, S., Maclaren, L.A., Bilodeau, J.F. Endocrinology (2005) [Pubmed]
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