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Gene Review

pobA  -  4-hydroxybenzoate 3-monooxygenase

Acinetobacter sp. ADP1

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Disease relevance of pobA


High impact information on pobA

  • The negative effect of protocatechuate on pobA expression is not based on a direct sensing of the metabolite by PobR, the specific regulator of pobA expression [4].
  • Linkage analysis showed that hcaC is linked to pobA [5].
  • These regulators may affect pobA expression by lowering the PcaK-mediated uptake of 4-hydroxybenzoate [6].
  • A model is presented in which BenM and CatM prevent pobA expression indirectly during growth on benzoate [6].
  • Growth on organic acids such as succinate, fumarate, and acetate allowed higher levels of pobA expression [6].

Chemical compound and disease context of pobA


Biological context of pobA


Associations of pobA with chemical compounds

  • For this purpose, two model hybrid strains of A. calcoaceticus were created, in which a DNA fragment carrying catBCIJFD genes for catabolic degradation of catechol was inserted into pobA in opposite directions of each other, and their genetic stabilities were experimentally examined [8].

Other interactions of pobA

  • Mutants selected on this medium contained the original mutation in pcaD and also carried spontaneous mutations in pobA [7].

Analytical, diagnostic and therapeutic context of pobA


  1. Identification of the transcriptional activator pobR and characterization of its role in the expression of pobA, the structural gene for p-hydroxybenzoate hydroxylase in Acinetobacter calcoaceticus. DiMarco, A.A., Averhoff, B., Ornston, L.N. J. Bacteriol. (1993) [Pubmed]
  2. Evolutionary divergence of pobA, the structural gene encoding p-hydroxybenzoate hydroxylase in an Acinetobacter calcoaceticus strain well-suited for genetic analysis. DiMarco, A.A., Averhoff, B.A., Kim, E.E., Ornston, L.N. Gene (1993) [Pubmed]
  3. Analysis of the pobA and pobR genes controlling expression of p-hydroxybenzoate hydroxylase in Azotobacter chroococcum. Quinn, J.A., McKay, D.B., Entsch, B. Gene (2001) [Pubmed]
  4. Multiple-Level Regulation of Genes for Protocatechuate Degradation in Acinetobacter baylyi Includes Cross-Regulation. Siehler, S.Y., Dal, S., Fischer, R., Patz, P., Gerischer, U. Appl. Environ. Microbiol. (2007) [Pubmed]
  5. Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1. Smith, M.A., Weaver, V.B., Young, D.M., Ornston, L.N. Appl. Environ. Microbiol. (2003) [Pubmed]
  6. Transcriptional cross-regulation of the catechol and protocatechuate branches of the beta-ketoadipate pathway contributes to carbon source-dependent expression of the Acinetobacter sp. strain ADP1 pobA gene. Brzostowicz, P.C., Reams, A.B., Clark, T.J., Neidle, E.L. Appl. Environ. Microbiol. (2003) [Pubmed]
  7. Selection of Acinetobacter calcoaceticus mutants deficient in the p-hydroxybenzoate hydroxylase gene (pobA), a member of a supraoperonic cluster. Hartnett, G.B., Averhoff, B., Ornston, L.N. J. Bacteriol. (1990) [Pubmed]
  8. Cloning of catBCIJFD genes for catechol degradation into chromosomal pobA and genetic stability of the recombinant Acinetobacter calcoaceticus. Jeong, E.Y., Ornston, L.N., Choi, S.H. Biosci. Biotechnol. Biochem. (1996) [Pubmed]
  9. Regulation of p-hydroxybenzoate hydroxylase synthesis by PobR bound to an operator in Acinetobacter calcoaceticus. DiMarco, A.A., Ornston, L.N. J. Bacteriol. (1994) [Pubmed]
  10. Mutation analysis of PobR and PcaU, closely related transcriptional activators in acinetobacter. Kok, R.G., D'Argenio, D.A., Ornston, L.N. J. Bacteriol. (1998) [Pubmed]
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