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Gene Review

GPX7  -  glutathione peroxidase 7

Homo sapiens

Synonyms: CL683, FLJ14777, GPX6, GPx-7, GSHPx-7, ...
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Disease relevance of GPX7

  • Thus, NPGPx plays an essential role in breast cancer cells in alleviating oxidative stress generated from polyunsaturated fatty acid metabolism [1].
  • After confirming the cross-reactivity of the antibody in suppressing the IL-6-mediated proliferation of rat liver cells, GPX7 was injected once a week at doses of 1 (low dose) or 4 (high dose) mg/kg body weight (BW) [2].

High impact information on GPX7


Biological context of GPX7


Anatomical context of GPX7

  • The values of the trabecular osteoclast surface and number in the GPX7 high-dose group were significantly smaller than those in the OVX controls [2].
  • Three mAbs (GPX7, GPX22 and GPZ35) were shown to inhibit IL-6-mediated biological responses such as Ig production in a human B cell line and proliferative responses of a human Lennert's lymphoma-derived T cell line, a human myeloma cell line, and a mouse pro-B cell line-derived transfectant expressing human gp130 [3].

Associations of GPX7 with chemical compounds


  1. Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. Utomo, A., Jiang, X., Furuta, S., Yun, J., Levin, D.S., Wang, Y.C., Desai, K.V., Green, J.E., Chen, P.L., Lee, W.H. J. Biol. Chem. (2004) [Pubmed]
  2. Effect of monoclonal anti-human gp130 antibody (GPX7) on bone turnover in normal and ovariectomized rats. Nishida, S., Okimoto, N., Okazaki, Y., Yamaguchi, A., Kumegawa, M., Yasukawa, K., Murayama, K., Nakamura, T. Calcif. Tissue Int. (1998) [Pubmed]
  3. Preparation of monoclonal antibodies against the IL-6 signal transducer, gp130, that can inhibit IL-6-mediated functions. Saito, T., Taga, T., Miki, D., Futatsugi, K., Yawata, H., Kishimoto, T., Yasukawa, K. J. Immunol. Methods (1993) [Pubmed]
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