Gene Review:
Pdlim2 - PDZ and LIM domain 2
Rattus norvegicus
Synonyms:
PDZ and LIM domain protein 2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text.
Read more.
Welcome to WikiGenes!
If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text.Ideally this entry shall become one comprehensive and continuous article. Bulleted lists, for instance, were only used because it is impossible to automatically integrate independent facts into a continuous text.
Much of the current information on this page has been automatically compiled from Pubmed.
This precompiled information serves as a substrate and matrix to embed your contributions, but it is by no means the final word - Homo sapiens can do much better!
WikiGenes is a non-profit and open access community project - Read more.
High impact information on Pdlim2
- In transfected COS-7 cells, complexes of Pdlim2 and alpha-actinin-1 were preferentially located along the basal aspect [1].
- Pdlim2 and alpha-actinins were co-localized mainly to stress fibers after transfection into COS-7 cells [1].
- Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A [1].
- METHODS: cDNA encoding Pdlim2 was identified in a cDNA library of transcripts expressed in the tissues of the rat eye irido-corneal angle [1].
- The Pdlim2 gene was specifically expressed in the corneal epithelial cells, but not in the corneal stroma and endothelium nor in other ocular tissues [1].
Anatomical context of Pdlim2
- CONCLUSIONS: These results suggest that Pdlim2, like other ALP subfamily members, may act as an adapter that directs other proteins to the cytoskeleton [1].
Analytical, diagnostic and therapeutic context of Pdlim2
- Intracellular localization of Pdlim2 was investigated by confocal microscopy [1].
- The expression pattern of the Pdlim2 gene was studied by Northern blot analysis and in situ hybridization [1].
References
- Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A. Torrado, M., Senatorov, V.V., Trivedi, R., Fariss, R.N., Tomarev, S.I. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg