The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt
  • Ensembl

Table of contents

About

Terms

 

Gene Review: 

Actc1  -  actin, alpha, cardiac muscle 1

Rattus norvegicus

Synonyms: Actc, Actin, alpha cardiac muscle 1, Alpha-cardiac actin
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Actc1

 

High impact information on Actc1

  • The "fetal" beta-myosin heavy chain (MHC) was up-regulated about four-fold, whereas the "adult" alpha MHC was inhibited greater than 50-60%; expression of alpha-skeletal actin increased approximately two-fold, with little or no change in alpha-cardiac actin [2].
  • Expression of the mouse alpha-cardiac actin gene in skeletal and cardiac muscle is regulated by enhancers lying 5' to the proximal promoter [3].
  • The cell clones do not spontaneously contract, yet they express several cardiac-specific (cardiac troponin-C, alpha-cardiac actin) and associated genes (Connexin 43, Early growth response gene-1) with stable expression of several genes determined through the 28th passage [4].
  • We found that regenerating muscle shows that embryonic pattern of alpha-actin mRNAs in the early stage and concluded that the recovery of alpha-skeletal actin mRNA expression to the adult pattern is influenced by innervation, while alpha-cardiac actin mRNA expression is nerve independent [5].
  • While the alpha-cardiac actin showed a marked preference for sarcomeres, the alpha-smooth muscle isoproteins had an intermediate specificity and could either be preferentially incorporated into stress fiber-like filaments (SFLF) and in some cells to a lesser extent into myofibrils as well [6].
 

Biological context of Actc1

  • METHODS: We thus investigated the gene expression of the transcription factors GATA-4, Nkx2.5, MEF-2c, and Oct-1 and of the downstream target genes atrial and brain natriuretic peptide, alpha- and beta-myosin heavy chain, alpha-cardiac actin, and alpha-skeletal actin [7].
  • To address this question, we have looked at the alpha- and beta-MHC, and at the alpha-skeletal and alpha-cardiac actin (alpha-skel act and alpha-card act) isomRNA transitions during development and senescence, both in rat and human hearts [8].
 

Analytical, diagnostic and therapeutic context of Actc1

  • Electrical stimulation of cardiocyte contraction did not enhance alpha-cardiac actin or myosin heavy chain (alpha+beta) mRNA transcript levels relative to 28S rRNA during the period of rapid growth that occurred over the first 48 hours [9].

References

  1. Differences in expression of sarcoplasmic reticulum Ca2+-ATPase and Na+-Ca2+ exchanger genes between adjacent and remote noninfarcted myocardium after myocardial infarction. Yoshiyama, M., Takeuchi, K., Hanatani, A., Kim, S., Omura, T., Toda, I., Teragaki, M., Akioka, K., Iwao, H., Yoshikawa, J. J. Mol. Cell. Cardiol. (1997) [Pubmed]
  2. Peptide growth factors can provoke "fetal" contractile protein gene expression in rat cardiac myocytes. Parker, T.G., Packer, S.E., Schneider, M.D. J. Clin. Invest. (1990) [Pubmed]
  3. Characterization of a cardiac-specific enhancer, which directs {alpha}-cardiac actin gene transcription in the mouse adult heart. Lemonnier, M., Buckingham, M.E. J. Biol. Chem. (2004) [Pubmed]
  4. Formation of fetal rat cardiac cell clones by retroviral transformation: retention of select myocyte characteristics. Engelmann, G.L., Birchenall-Roberts, M.C., Ruscetti, F.W., Samarel, A.M. J. Mol. Cell. Cardiol. (1993) [Pubmed]
  5. Expression of alpha-cardiac and alpha-skeletal actin mRNAs in relation to innervation in regenerating and non-regenerating rat skeletal muscles. Toyofuku, T., Hoffman, J.R., Zak, R., Carlson, B.M. Dev. Dyn. (1992) [Pubmed]
  6. Molecular analysis of protein sorting during biogenesis of muscle cytoarchitecture. Perriard, J.C., von Arx, P., Bantle, S., Eppenberger, H.M., Eppenberger-Eberhardt, M., Messerli, M., Soldati, T. Symp. Soc. Exp. Biol. (1992) [Pubmed]
  7. Reprogramming of gene expression in cultured cardiomyocytes and in explanted hearts by the myosin ATPase inhibitor butanedione monoxime. Thum, T., Borlak, J. Transplantation (2001) [Pubmed]
  8. Regulation of myosin heavy chain and actin isogenes during cardiac growth and hypertrophy. Schwartz, K., Carrier, L., Chassagne, C., Wisnewsky, C., Boheler, K.R. Symp. Soc. Exp. Biol. (1992) [Pubmed]
  9. Electrical stimulation of contractile activity accelerates growth of cultured neonatal cardiocytes. Johnson, T.B., Kent, R.L., Bubolz, B.A., McDermott, P.J. Circ. Res. (1994) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities