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Actc1  -  actin, alpha, cardiac muscle 1

Mus musculus

Synonyms: Actc, Actc-1, Actin, alpha cardiac muscle 1, Alpha-cardiac actin, alphac-actin
 
 
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High impact information on Actc1

  • In addition, the usual decline in the level of mouse alpha-cardiac actin transcripts was not observed; instead, after fusion with human fibroblasts the levels increased [1].
  • Analysis of the progeny of the interspecies mouse backcross (DBA/2 X SPE) X DBA/2 showed that the alpha-subunit gene cosegregates with the alpha-cardiac actin gene on chromosome 17, that the beta-subunit gene is located on chromosome 11, and that the gamma- and delta-subunit genes cosegregate and are located on chromosome 1 [2].
  • To gain insight into the cellular mechanisms that underlie cardiogenesis, we have used a retrospective clonal approach based on the spontaneous recombination of an nlaacZ reporter gene targeted to the murine alpha-cardiac actin locus [3].
  • BC3H1 cells also do not upregulate alpha-cardiac actin or fast myosin light chain, nor do they form multinucleate myotubes during differentiation [4].
  • Upon fusion with muscle cells to form heterokaryons, expression of the transfected alpha-cardiac actin gene promoter can be induced [5].
 

Biological context of Actc1

 

Anatomical context of Actc1

 

Associations of Actc1 with chemical compounds

  • Placement of this sequence in the corresponding 3' position both in the alpha-cardiac-actin gene and in the neomycin-resistance gene in pSV2-neo confers the beta-actin mRNA regulatory pattern when these constructs are stably introduced into C2C12 cells [12].
  • Developmentally regulated expression is also seen with the alpha-cardiac actin (320 bp) and acetylcholine receptor alpha-subunit (850 bp) upstream sequences in the primary culture system [13].
 

Regulatory relationships of Actc1

  • The present study demonstrates a significant functional correlation between alpha-actin isoform content and cardiac contractile function and also that alpha-skeletal actin may promote an increased contractile function in the heart compared with alpha-cardiac actin [14].
 

Other interactions of Actc1

  • Among these is an "MLC-sequence" (CCTTTTATAG) common to all MLC genes, including those of chick and rat, and a "cardiac sequence" common to the mouse MLC1A, MLC1V and alpha-cardiac actin genes expressed in the heart [15].
  • In the myotome, an intense hybridization signal for alpha-cardiac and a weak signal for alpha-skeletal actin transcripts are detectable prior to myosin mRNAs, whereas in the limb alpha-cardiac actin transcripts accumulate with myosin transcripts before alpha-skeletal actin mRNA is detectable [16].
  • The cardiac actin locus (Actc-1) is not on mouse chromosome 17 but is linked to beta 2-microglobulin on chromosome 2 [17].
  • CONCLUSIONS: IgM antibodies against alpha-cardiac actin and HSP60, which were induced by repetitive CVB3 infection, may play an important role in the pathophysiology of the subsequent cardiac dysfunction and dilatation [18].
 

Analytical, diagnostic and therapeutic context of Actc1

References

  1. The pattern of actin expression in human fibroblast x mouse muscle heterokaryons suggests that human muscle regulatory factors are produced. Hardeman, E.C., Chiu, C.P., Minty, A., Blau, H.M. Cell (1986) [Pubmed]
  2. Chromosomal localization of muscle nicotinic acetylcholine receptor genes in the mouse. Heidmann, O., Buonanno, A., Geoffroy, B., Robert, B., Guénet, J.L., Merlie, J.P., Changeux, J.P. Science (1986) [Pubmed]
  3. Oriented clonal cell growth in the developing mouse myocardium underlies cardiac morphogenesis. Meilhac, S.M., Esner, M., Kerszberg, M., Moss, J.E., Buckingham, M.E. J. Cell Biol. (2004) [Pubmed]
  4. Aberrant regulation of MyoD1 contributes to the partially defective myogenic phenotype of BC3H1 cells. Brennan, T.J., Edmondson, D.G., Olson, E.N. J. Cell Biol. (1990) [Pubmed]
  5. In vivo system for characterizing clonal variation and tissue-specific gene regulatory factors based on function. Hardeman, E.C., Minty, A., Benton-Vosman, P., Kedes, L., Blau, H.M. J. Cell Biol. (1988) [Pubmed]
  6. Novel muscle-specific enhancer sequences upstream of the cardiac actin gene. Biben, C., Kirschbaum, B.J., Garner, I., Buckingham, M. Mol. Cell. Biol. (1994) [Pubmed]
  7. The avian cardiac alpha-actin promoter is regulated through a pair of complex elements composed of E boxes and serum response elements that bind both positive- and negative-acting factors. Moss, J.B., McQuinn, T.C., Schwartz, R.J. J. Biol. Chem. (1994) [Pubmed]
  8. Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle. Gunning, P.W., Ferguson, V., Brennan, K.J., Hardeman, E.C. J. Cell. Sci. (2001) [Pubmed]
  9. Transcriptional regulation of actin and myosin genes during differentiation of a mouse muscle cell line. Cox, R.D., Garner, I., Buckingham, M.E. Differentiation (1990) [Pubmed]
  10. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Itskovitz-Eldor, J., Schuldiner, M., Karsenti, D., Eden, A., Yanuka, O., Amit, M., Soreq, H., Benvenisty, N. Mol. Med. (2000) [Pubmed]
  11. Impact of alpha-skeletal actin but not alpha-cardiac actin on myoblast morphology. Gunning, P., Ferguson, V., Brennan, K., Hardeman, E. Cell Struct. Funct. (1997) [Pubmed]
  12. A 40-base-pair sequence in the 3' end of the beta-actin gene regulates beta-actin mRNA transcription during myogenesis. DePonti-Zilli, L., Seiler-Tuyns, A., Paterson, B.M. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  13. Functional activity of the two promoters of the myosin alkali light chain gene in primary muscle cell cultures: comparison with other muscle gene promoters and other culture systems. Daubas, P., Klarsfeld, A., Garner, I., Pinset, C., Cox, R., Buckingham, M. Nucleic Acids Res. (1988) [Pubmed]
  14. Alpha-skeletal actin is associated with increased contractility in the mouse heart. Hewett, T.E., Grupp, I.L., Grupp, G., Robbins, J. Circ. Res. (1994) [Pubmed]
  15. Promoter analysis of myosin alkali light chain genes expressed in mouse striated muscle. Cohen, A., Barton, P.J., Robert, B., Garner, I., Alonso, S., Buckingham, M.E. Nucleic Acids Res. (1988) [Pubmed]
  16. Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles. Ontell, M., Ontell, M.P., Sopper, M.M., Mallonga, R., Lyons, G., Buckingham, M. Development (1993) [Pubmed]
  17. The cardiac actin locus (Actc-1) is not on mouse chromosome 17 but is linked to beta 2-microglobulin on chromosome 2. Crosby, J.L., Phillips, S.J., Nadeau, J.H. Genomics (1989) [Pubmed]
  18. Identification of autoantibodies with the corresponding antigen for repetitive coxsackievirus infection-induced cardiomyopathy. Takata, S., Nakamura, H., Umemoto, S., Yamaguchil, K., Sekine, T., Kato, T., Nishioka, K., Matsuzaki, M. Circ. J. (2004) [Pubmed]
 
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