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Gene Review:

UL2 - uracil-DNA glycosylase

Suid herpesvirus 1

Fuchs, W. et al., DeMarchi, J.M. et al., Kupershmidt, S. et al., Klupp, B.G. et al.

Fuchs, Mettenleiter,

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Disease relevance of UL2

Deduced proteins exhibited homology to uracil-DNA glycosylase encoded by HSV-1 ORF UL2 (54% identity) and gL encoded by HSV-1 ORF UL1 (24% identity), respectively [1].
The predicted ILTV protein encoded upstream of UL2 possesses limited sequence homology to the UL1 gene product of herpesviruses, the structural glycoprotein L. The presence of a N-terminal signal sequence, a conserved N-glycosylation site and two conserved cysteine residues indicates a similar function of the putative ILTV protein [2].
Within the UL2, a sequence that fits the consensus sequence of the NF1 binding site, as well as one that has partial homology to the binding site of UL9 of herpes simplex virus, is present [3].

High impact information on UL2

Furthermore, the last 82 nucleotides at the left end of the L component (and of the genome) are repeated in inverted form (inverted repeat within the L component [IRL]) approximately 350 to 600 nucleotides downstream (depending on the virus isolate) bracketing the UL2 component [4].

References

Identification and characterization of a novel structural glycoprotein in pseudorabies virus, gL. Klupp, B.G., Baumeister, J., Karger, A., Visser, N., Mettenleiter, T.C. J. Virol. (1994) [Pubmed]
DNA sequence and transcriptional analysis of the UL1 to UL5 gene cluster of infectious laryngotracheitis virus. Fuchs, W., Mettenleiter, T.C. J. Gen. Virol. (1996) [Pubmed]
Analysis of an origin of DNA replication located at the L terminus of the genome of pseudorabies virus. Kupershmidt, S., DeMarchi, J.M., Lu, Z.Q., Ben-Porat, T. J. Virol. (1991) [Pubmed]
Structural organization of the termini of the L and S components of the genome of pseudorabies virus. DeMarchi, J.M., Lu, Z.Q., Rall, G., Kupershmidt, S., Ben-Porat, T. J. Virol. (1990) [Pubmed]

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