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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rap1a  -  RAP1A, member of RAS oncogene family

Rattus norvegicus

Synonyms: Krev1, RAP-1A, Ras-related protein Krev-1, Ras-related protein Rap-1A, rap 1A
 
 
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High impact information on Rap1a

 

Anatomical context of Rap1a

  • Coincident induction of K rev-1/rap 1A, rap 1B and H-ras mRNAs in the rat spinal cord by noxious stimulation [4].
 

Associations of Rap1a with chemical compounds

  • It had previously been shown that a rap1 protein (also named Krev-1 or smg p21) could be phosphorylated on serine residues by the cAMP-dependent protein kinase (PKA) in vitro as well as in intact platelets stimulated by prostaglandin E1 [5].
 

Other interactions of Rap1a

 

Analytical, diagnostic and therapeutic context of Rap1a

  • We report here using Northern blot analysis with these cDNA probes that noxious stimulation causes a marked and coincident increase in rap 1A, rap 1B and H-ras mRNAs in the rat spinal cord [4].

References

  1. Defining the critical gene expression changes associated with expression and suppression of the tumorigenic and metastatic phenotype in Ha-ras-transformed cloned rat embryo fibroblast cells. Su, Z.Z., Austin, V.N., Zimmer, S.G., Fisher, P.B. Oncogene (1993) [Pubmed]
  2. Evidence for Rap1 in vascular smooth muscle cells. Regulation of their expression by platelet-derived growth factor BB. Quarck, R., Bryckaert, M., Magnier, C., Corvazier, E., Bredoux, R., de Gunzburg, J., Fontenay, M., Tobelem, G., Enouf, J. FEBS Lett. (1994) [Pubmed]
  3. Possible involvement of Rap1 and Ras in glutamatergic synaptic transmission. Imamura, Y., Matsumoto, N., Kondo, S., Kitayama, H., Noda, M. Neuroreport (2003) [Pubmed]
  4. Coincident induction of K rev-1/rap 1A, rap 1B and H-ras mRNAs in the rat spinal cord by noxious stimulation. Urayama, O., Murakoshi, T., Kubota, M., Hara, Y., Chihara, J., Ikawa, Y. Brain Res. Mol. Brain Res. (1997) [Pubmed]
  5. The cAMP-dependent protein kinase phosphorylates the rap1 protein in vitro as well as in intact fibroblasts, but not the closely related rap2 protein. Lerosey, I., Pizon, V., Tavitian, A., de Gunzburg, J. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  6. Expression of Krev-1 and c-H-ras proto-oncogenes in the rat spinal cord and the effects of noxious stimulation. Murakoshi, T., Hamasaki, H., Ikawa, Y., Urayama, O. Regul. Pept. (1993) [Pubmed]
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