Gene Review:
R - Roughened
Drosophila melanogaster
Synonyms:
BEST:GH18528, C-ras3, CG1956, D-Rap1, DRap, ...
- Biological characterization of Drosophila Rapgap1, a GTPase activating protein for Rap1. Chen, F., Barkett, M., Ram, K.T., Quintanilla, A., Hariharan, I.K. Proc. Natl. Acad. Sci. U.S.A. (1997)
- The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination. Hariharan, I.K., Carthew, R.W., Rubin, G.M. Cell (1991)
- The Doa locus encodes a member of a new protein kinase family and is essential for eye and embryonic development in Drosophila melanogaster. Yun, B., Farkas, R., Lee, K., Rabinow, L. Genes Dev. (1994)
- The Rap1 GTPase functions as a regulator of morphogenesis in vivo. Asha, H., de Ruiter, N.D., Wang, M.G., Hariharan, I.K. EMBO J. (1999)
- Ras-independent activation of ERK signaling via the torso receptor tyrosine kinase is mediated by Rap1. Mishra, S., Smolik, S.M., Forte, M.A., Stork, P.J. Curr. Biol. (2005)
- rap gene encodes Fizzy-related protein (Fzr) and regulates cell proliferation and pattern formation in the developing Drosophila eye-antennal disc. Pimentel, A.C., Venkatesh, T.R. Dev. Biol. (2005)
- The genetics of the Dras3-Roughened-ecdysoneless chromosomal region (62B3-4 to 62D3-4) in Drosophila melanogaster: analysis of recessive lethal mutations. Sliter, T.J., Henrich, V.C., Tucker, R.L., Gilbert, L.I. Genetics (1989)
- The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo. Boettner, B., Harjes, P., Ishimaru, S., Heke, M., Fan, H.Q., Qin, Y., Van Aelst, L., Gaul, U. Genetics (2003)
- A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Mirey, G., Balakireva, M., L'Hoste, S., Rossé, C., Voegeling, S., Camonis, J. Mol. Cell. Biol. (2003)
- The PDZ-GEF dizzy regulates cell shape of migrating macrophages via Rap1 and integrins in the Drosophila embryo. Huelsmann, S., Hepper, C., Marchese, D., Knöll, C., Reuter, R. Development (2006)
- Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis. Wang, H., Singh, S.R., Zheng, Z., Oh, S.W., Chen, X., Edwards, K., Hou, S.X. Dev. Cell (2006)
- Rap1 GTPase regulation of adherens junction positioning and cell adhesion. Knox, A.L., Brown, N.H. Science (2002)
- Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway. Lee, J.H., Cho, K.S., Lee, J., Kim, D., Lee, S.B., Yoo, J., Cha, G.H., Chung, J. Mol. Cell. Biol. (2002)
- Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. Pizon, V., Chardin, P., Lerosey, I., Olofsson, B., Tavitian, A. Oncogene (1988)
- Maternal and embryonic transcripts of Drosophila proto-oncogenes are expressed in Schneider 2 culture cells but not in l(2)gl transformed neuroblasts. Kimchie, Z., Segev, O., Lev, Z. Cell Differ. Dev. (1989)