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Gene Review:

Mgat3 - mannosyl (beta-1,4-)-glycoprotein beta-1,4...

Rattus norvegicus

Synonyms: Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, GNT-III, GlcNAc-T III, Gnt3, N-acetylglucosaminyltransferase III, ...

Narasimhan, S. et al., Pascale, R. et al., Nishikawa, A. et al., Miyoshi, E. et al., Ihara, Y. et al., et al.

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Disease relevance of Mgat3

High expression of an N-acetylglucosaminyltransferase III in 3'-methyl DAB-induced hepatoma and ascites hepatoma [1].

High impact information on Mgat3

Activities and mRNA levels of N-acetylglucosaminyltransferase III and V (GnT-III and GnT-V, respectively) were determined during hepatocarcinogenesis in this rat using a LEA (Long-Evans with an agouti color) rat as a control [2].
Overexpression of N-acetylglucosaminyltransferase III disrupts the tyrosine phosphorylation of Trk with resultant signaling dysfunction in PC12 cells treated with nerve growth factor [3].
The nodules had significant N-acetylglucosaminyltransferase III activity (0.78-2.18 nmol GlcNAc transferred/h/mg of protein), while the surrounding liver, the regenerating liver (24 h after partial hepatectomy), and the control liver had negligible activity (0.02-0.03 nmol/h/mg of protein) [4].
Expression of N-acetylglucosaminyltransferase III in hepatic nodules during rat liver carcinogenesis promoted by orotic acid [4].
N-Acetylglucosaminyltransferase III was assayed using glycopeptide GlcNAc beta 1,2Man alpha 1,6(GlcNAc beta 1,2Man alpha 1,3)Man beta 1, 4GlcNAc beta 1,4GlcNAc-Asn as substrate and, as enzyme sources, microsomal membranes of the hepatic nodules, surrounding liver, regenerating liver, and age- and sex-matched control liver [4].

Chemical compound and disease context of Mgat3

N-Acetylglucosaminyltransferase III, IV and V activities were assayed in various rat tissues and hepatomas using the same fluorescence-labeled sugar chain, GlcNAc beta 1-2Man alpha 1-3-(GlcNAc beta 1-2Man alpha 1-6)Man beta 1-4GlcNAc beta 1-4GlcNAc-2-aminopyridine as a substrate [5].

Associations of Mgat3 with chemical compounds

Our earlier studies revealed that N-acetylglucosaminyltransferase III (GnTase III), which catalyzes the insertion of a bisecting N-acetylglucosamine (bi-Gn) in the complex-type N-linked glycans of cellular glycoproteins, is present in hepatic nodules promoted by the orotic acid model [6].

Analytical, diagnostic and therapeutic context of Mgat3

A method for the determination of N-acetylglucosaminyltransferase III activity in rat tissues involving HPLC [7].

References

High expression of an N-acetylglucosaminyltransferase III in 3'-methyl DAB-induced hepatoma and ascites hepatoma. Nishikawa, A., Fujii, S., Sugiyama, T., Hayashi, N., Taniguchi, N. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
N-acetylglucosaminyltransferase III and V messenger RNA levels in LEC rats during hepatocarcinogenesis. Miyoshi, E., Nishikawa, A., Ihara, Y., Gu, J., Sugiyama, T., Hayashi, N., Fusamoto, H., Kamada, T., Taniguchi, N. Cancer Res. (1993) [Pubmed]
Overexpression of N-acetylglucosaminyltransferase III disrupts the tyrosine phosphorylation of Trk with resultant signaling dysfunction in PC12 cells treated with nerve growth factor. Ihara, Y., Sakamoto, Y., Mihara, M., Shimizu, K., Taniguchi, N. J. Biol. Chem. (1997) [Pubmed]
Expression of N-acetylglucosaminyltransferase III in hepatic nodules during rat liver carcinogenesis promoted by orotic acid. Narasimhan, S., Schachter, H., Rajalakshmi, S. J. Biol. Chem. (1988) [Pubmed]
Determination of N-acetylglucosaminyltransferases III, IV and V in normal and hepatoma tissues of rats. Nishikawa, A., Gu, J., Fujii, S., Taniguchi, N. Biochim. Biophys. Acta (1990) [Pubmed]
Expression of N-acetylglucosaminyltransferase III in hepatic nodules generated by different models of rat liver carcinogenesis. Pascale, R., Narasimhan, S., Rajalakshmi, S. Carcinogenesis (1989) [Pubmed]
A method for the determination of N-acetylglucosaminyltransferase III activity in rat tissues involving HPLC. Nishikawa, A., Fujii, S., Sugiyama, T., Taniguchi, N. Anal. Biochem. (1988) [Pubmed]

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