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Gene Review

Mgat3  -  mannoside acetylglucosaminyltransferase 3

Mus musculus

Synonyms: 1110038J12Rik, AI848272, Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, GNT-III, GlcNAc-T III, ...
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Disease relevance of Mgat3


High impact information on Mgat3


Chemical compound and disease context of Mgat3

  • Using B16-hm mouse melanoma cells stably expressing GnT-III activity as positive transfectants, the effect of bisecting N-acetylglucosamine on the function of CD44 was analyzed in association with adhesion to hyaluronate and tumor spread in mice [9].

Biological context of Mgat3


Anatomical context of Mgat3


Associations of Mgat3 with chemical compounds

  • Isolation, characterization and inactivation of the mouse Mgat3 gene: the bisecting N-acetylglucosamine in asparagine-linked oligosaccharides appears dispensable for viability and reproduction [10].
  • In the absence of the bisecting GlcNAc in Mgat3-/- mice, the factor is reduced in activity, and tumor progression is severely retarded [1].
  • However, histological examination showed that Mgat3-/- livers had significant numbers of basophilic foci, and by 10-12 months after diethylnitrosamine injection, tumors had developed in Mgat3-/- mice [1].
  • Following DEN injection and phenobarbitol treatment, however, no significant differences were observed between MUP/Mgat3 transgenic and control mice in either tumor numbers or liver weight [8].
  • E(4)-PHA lectin blot analyses showed that the levels of bisecting GlcNAc structures on the integrin alpha(5) subunit as well as alpha(2) and alpha(3) subunits immunoprecipitated from GnT-III transfectants were substantially increased [2].

Regulatory relationships of Mgat3


Other interactions of Mgat3


Analytical, diagnostic and therapeutic context of Mgat3


  1. Progression of hepatic neoplasms is severely retarded in mice lacking the bisecting N-acetylglucosamine on N-glycans: evidence for a glycoprotein factor that facilitates hepatic tumor progression. Bhaumik, M., Harris, T., Sundaram, S., Johnson, L., Guttenplan, J., Rogler, C., Stanley, P. Cancer Res. (1998) [Pubmed]
  2. Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration. Isaji, T., Gu, J., Nishiuchi, R., Zhao, Y., Takahashi, M., Miyoshi, E., Honke, K., Sekiguchi, K., Taniguchi, N. J. Biol. Chem. (2004) [Pubmed]
  3. Suppression of lung metastasis of B16 mouse melanoma by N-acetylglucosaminyltransferase III gene transfection. Yoshimura, M., Nishikawa, A., Ihara, Y., Taniguchi, S., Taniguchi, N. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. Aberrant glycosylation of E-cadherin enhances cell-cell binding to suppress metastasis. Yoshimura, M., Ihara, Y., Matsuzawa, Y., Taniguchi, N. J. Biol. Chem. (1996) [Pubmed]
  5. Bisecting GlcNAc structures act as negative sorting signals for cell surface glycoproteins in forskolin-treated rat hepatoma cells. Sultan, A.S., Miyoshi, E., Ihara, Y., Nishikawa, A., Tsukada, Y., Taniguchi, N. J. Biol. Chem. (1997) [Pubmed]
  6. Ectopic expression of N-acetylglucosaminyltransferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage. Ihara, Y., Yoshimura, M., Miyoshi, E., Nishikawa, A., Sultan, A.S., Toyosawa, S., Ohnishi, A., Suzuki, M., Yamamura, K., Ijuhin, N., Taniguchi, N. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. Reduced hepatocyte proliferation is the basis of retarded liver tumor progression and liver regeneration in mice lacking N-acetylglucosaminyltransferase III. Yang, X., Tang, J., Rogler, C.E., Stanley, P. Cancer Res. (2003) [Pubmed]
  8. New evidence for an extra-hepatic role of N-acetylglucosaminyltransferase III in the progression of diethylnitrosamine-induced liver tumors in mice. Yang, X., Bhaumik, M., Bhattacharyya, R., Gong, S., Rogler, C.E., Stanley, P. Cancer Res. (2000) [Pubmed]
  9. Remodeling of glycoconjugates on CD44 enhances cell adhesion to hyaluronate, tumor growth and metastasis in B16 melanoma cells expressing beta1,4-N-acetylglucosaminyltransferase III. Sheng, Y., Yoshimura, M., Inoue, S., Oritani, K., Nishiura, T., Yoshida, H., Ogawa, M., Okajima, Y., Matsuzawa, Y., Taniguchi, N. Int. J. Cancer (1997) [Pubmed]
  10. Isolation, characterization and inactivation of the mouse Mgat3 gene: the bisecting N-acetylglucosamine in asparagine-linked oligosaccharides appears dispensable for viability and reproduction. Priatel, J.J., Sarkar, M., Schachter, H., Marth, J.D. Glycobiology (1997) [Pubmed]
  11. Cloning and chromosomal mapping of the mouse Mgat3 gene encoding N-acetylglucosaminyltransferase III. Bhaumik, M., Seldin, M.F., Stanley, P. Gene (1995) [Pubmed]
  12. Molecular analysis of three gain-of-function CHO mutants that add the bisecting GlcNAc to N-glycans. Stanley, P., Sundaram, S., Tang, J., Shi, S. Glycobiology (2005) [Pubmed]
  13. Antibodies that recognize bisected complex N-glycans on cell surface glycoproteins can be made in mice lacking N-acetylglucosaminyltransferase III. Lee, J., Park, S.H., Stanley, P. Glycoconj. J. (2002) [Pubmed]
  14. Bisecting GlcNAc structure is implicated in suppression of stroma-dependent haemopoiesis in transgenic mice expressing N-acetylglucosaminyltransferase III. Yoshimura, M., Ihara, Y., Nishiura, T., Okajima, Y., Ogawa, M., Yoshida, H., Suzuki, M., Yamamura, K., Kanakura, Y., Matsuzawa, Y., Taniguchi, N. Biochem. J. (1998) [Pubmed]
  15. The addition of bisecting N-acetylglucosamine residues to E-cadherin down-regulates the tyrosine phosphorylation of beta-catenin. Kitada, T., Miyoshi, E., Noda, K., Higashiyama, S., Ihara, H., Matsuura, N., Hayashi, N., Kawata, S., Matsuzawa, Y., Taniguchi, N. J. Biol. Chem. (2001) [Pubmed]
  16. Reduction of the Gal-alpha1,3-Gal epitope of mouse endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene. Chung, T.W., Kim, K.S., Kim, C.H. Mol. Cells (2003) [Pubmed]
  17. beta1,4-N-Acetylglucosaminyltransferase III potentiates beta1 integrin-mediated neuritogenesis induced by serum deprivation in Neuro2a cells. Shigeta, M., Shibukawa, Y., Ihara, H., Miyoshi, E., Taniguchi, N., Gu, J. Glycobiology (2006) [Pubmed]
  18. A glycomic approach to hepatic tumors in N-acetylglucosaminyltransferase III (GnT-III) transgenic mice induced by diethylnitrosamine (DEN): identification of haptoglobin as a target molecule of GnT-III. Ekuni, A., Miyoshi, E., Ko, J.H., Noda, K., Kitada, T., Ihara, S., Endo, T., Hino, A., Honke, K., Taniguchi, N. Free Radic. Res. (2002) [Pubmed]
  19. Bisecting N-acetylglucosamine on K562 cells suppresses natural killer cytotoxicity and promotes spleen colonization. Yoshimura, M., Ihara, Y., Ohnishi, A., Ijuhin, N., Nishiura, T., Kanakura, Y., Matsuzawa, Y., Taniguchi, N. Cancer Res. (1996) [Pubmed]
  20. Remodeling of the major pig xenoantigen by N-acetylglucosaminyltransferase III in transgenic pig. Miyagawa, S., Murakami, H., Takahagi, Y., Nakai, R., Yamada, M., Murase, A., Koyota, S., Koma, M., Matsunami, K., Fukuta, D., Fujimura, T., Shigehisa, T., Okabe, M., Nagashima, H., Shirakura, R., Taniguchi, N. J. Biol. Chem. (2001) [Pubmed]
  21. N-acetylglucosaminyltransferase III, IV and V activities in Novikoff ascites tumour cells, mouse lymphoma cells and hen oviduct. Application of a sensitive and specific assay by use of high-performance liquid chromatography. Koenderman, A.H., Koppen, P.L., Koeleman, C.A., van den Eijnden, D.H. Eur. J. Biochem. (1989) [Pubmed]
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