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Gene Review

MGAT3  -  mannosyl (beta-1,4-)-glycoprotein beta-1,4...

Homo sapiens

Synonyms: Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, GGNT3, GNT-III, GNT3, GlcNAc-T III, ...
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Disease relevance of MGAT3


High impact information on MGAT3


Chemical compound and disease context of MGAT3


Biological context of MGAT3


Anatomical context of MGAT3


Associations of MGAT3 with chemical compounds


Regulatory relationships of MGAT3


Other interactions of MGAT3


Analytical, diagnostic and therapeutic context of MGAT3


  1. Expression of bisecting N-acetylglucosaminyltransferase-III in human hepatocarcinoma tissues, fetal liver tissues, and hepatoma cell lines of Hep3B and HepG2. Song, E.Y., Kang, S.K., Lee, Y.C., Park, Y.G., Chung, T.H., Kwon, D.H., Byun, S.M., Kim, C.H. Cancer Invest. (2001) [Pubmed]
  2. Selective suppression of N-acetylglucosaminyltransferase III activity in a human hepatoblastoma cell line transfected with hepatitis B virus. Miyoshi, E., Nishikawa, A., Ihara, Y., Hayashi, N., Fusamoto, H., Kamada, T., Taniguchi, N. Cancer Res. (1994) [Pubmed]
  3. N-Acetylglucosaminyltransferase III Antagonizes the Effect of N-Acetylglucosaminyltransferase V on {alpha}3beta1 Integrin-mediated Cell Migration. Zhao, Y., Nakagawa, T., Itoh, S., Inamori, K., Isaji, T., Kariya, Y., Kondo, A., Miyoshi, E., Miyazaki, K., Kawasaki, N., Taniguchi, N., Gu, J. J. Biol. Chem. (2006) [Pubmed]
  4. Cell cycle-dependent regulation of N-acetylglucosaminyltransferase-III in a human colon cancer cell line, Colo201. Kang, R., Ikeda, Y., Miyoshi, E., Wang, W., Li, W., Ihara, Y., Sheng, Y., Taniguchi, N. Arch. Biochem. Biophys. (2000) [Pubmed]
  5. Changes in N-acetylglucosaminyltransferase III, IV and V in renal cell carcinoma. Zhu, T.Y., Chen, H.L., Gu, J.X., Zhang, Y.F., Zhang, Y.K., Zhang, R.A. J. Cancer Res. Clin. Oncol. (1997) [Pubmed]
  6. Glycosylation differences between the normal and pathogenic prion protein isoforms. Rudd, P.M., Endo, T., Colominas, C., Groth, D., Wheeler, S.F., Harvey, D.J., Wormald, M.R., Serban, H., Prusiner, S.B., Kobata, A., Dwek, R.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  7. Carbohydrate analysis of immunoglobulin G myeloma proteins by lectin and high performance liquid chromatography: role of glycosyltransferases in the structures. Nishiura, T., Fujii, S., Kanayama, Y., Nishikawa, A., Tomiyama, Y., Iida, M., Karasuno, T., Nakao, H., Yonezawa, T., Taniguchi, N. Cancer Res. (1990) [Pubmed]
  8. A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet. Cao, J., Hawkins, E., Brozinick, J., Liu, X., Zhang, H., Burn, P., Shi, Y. J. Biol. Chem. (2004) [Pubmed]
  9. The hepatitis B virus X protein inhibits secretion of apolipoprotein B by enhancing the expression of N-acetylglucosaminyltransferase III. Kang, S.K., Chung, T.W., Lee, J.Y., Lee, Y.C., Morton, R.E., Kim, C.H. J. Biol. Chem. (2004) [Pubmed]
  10. N-acetylglucosaminyltransferase III in human serum, and liver and hepatoma tissues: increased activity in liver cirrhosis and hepatoma patients. Ishibashi, K., Nishikawa, A., Hayashi, N., Kasahara, A., Sato, N., Fujii, S., Kamada, T., Taniguchi, N. Clin. Chim. Acta (1989) [Pubmed]
  11. Beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase III activity in human B and T lymphocyte lines and in tonsillar B and T lymphocytes. Narasimhan, S., Lee, J.W., Cheung, R.K., Gelfand, E.W., Schachter, H. Biochem. Cell Biol. (1988) [Pubmed]
  12. Sequence analysis of the 5'-flanking region of the gene encoding human N-acetylglucosaminyltransferase III. Kim, Y.J., Park, J.H., Kim, K.S., Chang, J.E., Ko, J.H., Kim, M.H., Chung, D.H., Chung, T.W., Choe, I.S., Lee, Y.C., Kim, C.H. Gene (1996) [Pubmed]
  13. Kinetic basis for the donor nucleotide-sugar specificity of beta1, 4-N-acetylglucosaminyltransferase III. Ikeda, Y., Koyota, S., Ihara, H., Yamaguchi, Y., Korekane, H., Tsuda, T., Sasai, K., Taniguchi, N. J. Biochem. (2000) [Pubmed]
  14. Transfection of N-acetylglucosaminyltransferase III gene suppresses expression of hepatitis B virus in a human hepatoma cell line, HB611. Miyoshi, E., Ihara, Y., Hayashi, N., Fusamoto, H., Kamada, T., Taniguchi, N. J. Biol. Chem. (1995) [Pubmed]
  15. Overexpression of N-acetylglucosaminyltransferase III enhances the epidermal growth factor-induced phosphorylation of ERK in HeLaS3 cells by up-regulation of the internalization rate of the receptors. Sato, Y., Takahashi, M., Shibukawa, Y., Jain, S.K., Hamaoka, R., Miyagawa Ji, n.u.l.l., Yaginuma, Y., Honke, K., Ishikawa, M., Taniguchi, N. J. Biol. Chem. (2001) [Pubmed]
  16. Modification of pentasaccharide core of surface N-glycans during differentiation of HL-60 cells. Li, Z., Liu, A.H., Liu, F., Chen, H.L. Leuk. Res. (1998) [Pubmed]
  17. Biological consequences of overexpressing or eliminating N-acetylglucosaminyltransferase-TIII in the mouse. Stanley, P. Biochim. Biophys. Acta (2002) [Pubmed]
  18. Changes in the expression of N-acetylglucosaminyltransferase III, IV, V associated with the differentiation of HL-60 cells. Koenderman, A.H., Wijermans, P.W., van den Eijnden, D.H. FEBS Lett. (1987) [Pubmed]
  19. Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells. Shibukawa, Y., Takahashi, M., Laffont, I., Honke, K., Taniguchi, N. J. Biol. Chem. (2003) [Pubmed]
  20. Possible role for peptide-oligosaccharide interactions in differential oligosaccharide processing at asparagine-107 of the light chain and asparagine-297 of the heavy chain in a monoclonal IgG1 kappa. Savvidou, G., Klein, M., Grey, A.A., Dorrington, K.J., Carver, J.P. Biochemistry (1984) [Pubmed]
  21. Elevated expression of bisecting N-acetylglucosaminyltransferase-III gene in a human fetal hepatocyte cell line by hepatitis B virus. Shim, J.K., Lee, Y.C., Chung, T.H., Kim, C.H. J. Gastroenterol. Hepatol. (2004) [Pubmed]
  22. Serum N-acetylglucosaminyltransferase III activities in hepatocellular carcinoma. Mori, S., Aoyagi, Y., Yanagi, M., Suzuki, Y., Asakura, H. J. Gastroenterol. Hepatol. (1998) [Pubmed]
  23. Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus. Sasai, K., Ikeda, Y., Ihara, H., Honke, K., Taniguchi, N. J. Biol. Chem. (2003) [Pubmed]
  24. Gene transfection-mediated overexpression of beta1,4-N-acetylglucosamine bisecting oligosaccharides in glioma cell line U373 MG inhibits epidermal growth factor receptor function. Rebbaa, A., Yamamoto, H., Saito, T., Meuillet, E., Kim, P., Kersey, D.S., Bremer, E.G., Taniguchi, N., Moskal, J.R. J. Biol. Chem. (1997) [Pubmed]
  25. Enzymatic basis of sugar structures of alpha-fetoprotein in hepatoma and hepatoblastoma cell lines: correlation with activities of alpha 1-6 fucosyltransferase and N-acetylglucosaminyltransferases III and V. Ohno, M., Nishikawa, A., Koketsu, M., Taga, H., Endo, Y., Hada, T., Higashino, K., Taniguchi, N. Int. J. Cancer (1992) [Pubmed]
  26. Reducing Gal expression on the pig organ - a retrospective review. Ezzelarab, M., Cooper, D.K. Xenotransplantation (2005) [Pubmed]
  27. The biosynthesis of highly branched N-glycans: studies on the sequential pathway and functional role of N-acetylglucosaminyltransferases I, II, III, IV, V and VI. Brockhausen, I., Narasimhan, S., Schachter, H. Biochimie (1988) [Pubmed]
  28. Skin graft of double transgenic pigs of N-acetylglucosaminyltransferase III (GnT-III) and DAF (CD55) genes survived in cynomolgus monkey for 31 days. Fujita, T., Miyagawa, S., Ezoe, K., Saito, T., Sato, N., Takahagi, Y., Murakami, H., Matsunami, K., Shirakura, R., Taniguchi, N. Transpl. Immunol. (2004) [Pubmed]
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