Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Slc22a7-ps1 - solute carrier family 22 (organic anion...

Rattus norvegicus

Halwachs, S. et al., Kobayashi, Y. et al., Kusuhara, H. et al., Choudhuri, S. et al., Buist, S.C. et al., et al.

Kudo, Katakura, Sato, Kawashima,

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High impact information on OAT-2

Degenerate primers were designed based on the sequences conserved among OAT1, OAT2, and organic cation transporter 1 (OCT1), and reverse transcription-polymerase chain reaction was performed using rat brain poly(A)+ RNA [1].
Rat organic anion transporter 1 (Oat1), Oat2, and Oat3, members of the organic anion transporter family, transport some organic anions across cellular membranes [2].
RT-PCR analysis indicated gene expression of Oat2, Oatplal, Oatpla4, Oatplb2, Rfc-1/MTX-1, FOLR, Mrp1-6, mdr1, and Lrp [3].
OctN1 and N2, Oatp2, Oat2 and 3, and Cnt1 and 2 mRNAs expressions were detectable in choroid plexus, but the levels were lower compared with that in liver, kidney, or ileum [4].
There were no sex differences in the expression of rOAT1 mRNA. rOAT2 mRNA was abundant in the liver and weakly expressed in the kidney of male rats; however, the OAT2 gene was strongly expressed in both organs of females [5].

Anatomical context of OAT-2

Role of nitric oxide (NO) on the expression of organic anion transporter 2 (OAT2) located in sinusoidal domain of hepatocytes has been investigated [6].

Associations of OAT-2 with chemical compounds

Castration or estradiol treatment increased the level of OAT2 mRNA whereas treatment of castrated male rats with testosterone reduced it [7].

References

Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. Kusuhara, H., Sekine, T., Utsunomiya-Tate, N., Tsuda, M., Kojima, R., Cha, S.H., Sugiyama, Y., Kanai, Y., Endou, H. J. Biol. Chem. (1999) [Pubmed]
Gender-specific and developmental influences on the expression of rat organic anion transporters. Buist, S.C., Cherrington, N.J., Choudhuri, S., Hartley, D.P., Klaassen, C.D. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
Endogenous expression of liver-specific drug transporters for organic anions in the rat hepatocytoma fusion cell line HPCT-1E3. Halwachs, S., Kneuer, C., Honscha, W. Eur. J. Cell Biol. (2005) [Pubmed]
Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats. Choudhuri, S., Cherrington, N.J., Li, N., Klaassen, C.D. Drug Metab. Dispos. (2003) [Pubmed]
Differential gene expression of organic anion transporters in male and female rats. Kobayashi, Y., Hirokawa, N., Ohshiro, N., Sekine, T., Sasaki, T., Tokuyama, S., Endou, H., Yamamoto, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
Down-regulation of organic anion transporter 2 mRNA expression by nitric oxide in primary cultured rat hepatocytes. Cha, S.H., Kim, H.P., Jung, N.H., Lee, W.K., Kim, J.Y., Cha, Y.N. IUBMB Life (2002) [Pubmed]
Sex hormone-regulated renal transport of perfluorooctanoic acid. Kudo, N., Katakura, M., Sato, Y., Kawashima, Y. Chem. Biol. Interact. (2002) [Pubmed]

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