Gene Review:
Tpr - translocated promoter region, nuclear...
Rattus norvegicus
Synonyms:
Megator, NPC-associated intranuclear protein, Nucleoprotein TPR, Translocated promoter region protein
- Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. Frosst, P., Guan, T., Subauste, C., Hahn, K., Gerace, L. J. Cell Biol. (2002)
- Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr. Shah, S., Tugendreich, S., Forbes, D. J. Cell Biol. (1998)
- Activation of the JNK pathway is essential for transformation by the Met oncogene. Rodrigues, G.A., Park, M., Schlessinger, J. EMBO J. (1997)
- Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex. Byrd, D.A., Sweet, D.J., Panté, N., Konstantinov, K.N., Guan, T., Saphire, A.C., Mitchell, P.J., Cooper, C.S., Aebi, U., Gerace, L. J. Cell Biol. (1994)
- Loss of the exon encoding the juxtamembrane domain is essential for the oncogenic activation of TPR-MET. Vigna, E., Gramaglia, D., Longati, P., Bardelli, A., Comoglio, P.M. Oncogene (1999)
- Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis. Saucier, C., Papavasiliou, V., Palazzo, A., Naujokas, M.A., Kremer, R., Park, M. Oncogene (2002)
- Identification of tyrosine 489 in the carboxy terminus of the Tpr-Met oncoprotein as a major site of autophosphorylation. Kamikura, D.M., Naujokas, M.A., Park, M. Biochemistry (1996)
- Endotoxin shock: thermoregulatory mechanisms. Romanovsky, A.A., Shido, O., Sakurada, S., Sugimoto, N., Nagasaka, T. Am. J. Physiol. (1996)
- Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus. Fixman, E.D., Naujokas, M.A., Rodrigues, G.A., Moran, M.F., Park, M. Oncogene (1995)
- Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1. Fixman, E.D., Holgado-Madruga, M., Nguyen, L., Kamikura, D.M., Fournier, T.M., Wong, A.J., Park, M. J. Biol. Chem. (1997)