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Gene Review

Met  -  MET proto-oncogene, receptor tyrosine kinase

Rattus norvegicus

Synonyms: HGF receptor, HGF/SF receptor, Hepatocyte growth factor receptor, Proto-oncogene c-Met, SF receptor, ...
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Disease relevance of Met


High impact information on Met


Chemical compound and disease context of Met


Biological context of Met


Anatomical context of Met


Associations of Met with chemical compounds

  • Using immature rat GC, the present study investigated the effects of HGF within the estrogen biosynthetic pathway, concomitant with changes in c-Met and PKBalpha mRNA expression [14].
  • We also analyzed endogenous HGF expression and phosphorylation of c-Met/HGF receptor in the kidneys of glycerol-induced ARF rats [15].
  • The addition of bile acids into the culture medium had significantly delayed the process of de-differentiation and restrained the drastic elevation of c-Met (tauroursodeoxycholic acid > ursodeoxycholic acid) [8].
  • The nucleotide sequence of the rat c-met cDNA revealed that the HGF receptor is encoded within single open-reading frame as 190 kDa of a transmembrane glycoprotein consisting of 1,382 amino acids [16].
  • Treatment with celecoxib significantly delayed esophageal ulcer healing and suppressed ulceration-triggered increases in esophageal epithelial cell proliferation, c-Met mRNA and protein expression, and ERK2 activity [17].

Physical interactions of Met


Regulatory relationships of Met


Other interactions of Met

  • As a consequence of this rearrangement the Tpr-Met fusion oncoprotein is localized to the cytoplasm and is a constitutively activated kinase [21].
  • Differential distribution of Met and epidermal growth factor receptor in normal and carcinogen-treated rat liver [22].
  • Furthermore, 1 min after PHx, but not sham operation, urokinase-type plasminogen activator (u-PA) and u-PA receptor were observed in the immunoprecipitates of c-Met [23].
  • The TGF-alpha receptor EGFr appears primarily to mediate a proliferative signal, whereas mitogenic, motogenic, and morphogenic effects have been attributed to activation of the HGF receptor Met [22].
  • Growth factor enriched milieu induced a rapid loss of ASGPr with a significant increase of c-Met surface level and a decrease in c-Met protein level [8].

Analytical, diagnostic and therapeutic context of Met


  1. Enhanced expression of hepatocyte growth factor/c-Met by myocardial ischemia and reperfusion in a rat model. Ono, K., Matsumori, A., Shioi, T., Furukawa, Y., Sasayama, S. Circulation (1997) [Pubmed]
  2. Aberrant expression of hepatocyte growth factor and its receptor, c-Met, during sex hormone-induced prostatic carcinogenesis in the Noble rat. Tam, N.N., Chung, S.S., Lee, D.T., Wong, Y.C. Carcinogenesis (2000) [Pubmed]
  3. A potential cardioprotective role of hepatocyte growth factor in myocardial infarction in rats. Ueda, H., Nakamura, T., Matsumoto, K., Sawa, Y., Matsuda, H., Nakamura, T. Cardiovasc. Res. (2001) [Pubmed]
  4. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson, A., Helou, K., Wallenius, V., Hedrich, H.J., Szpirer, C., Levan, G. Cancer Res. (2001) [Pubmed]
  5. In situ activation pattern of Met docking site following renal injury and hypertrophy. Dekel, B., Biton, S., Yerushalmi, G.M., Altstock, R.T., Mittelman, L., Faletto, D., Smordinski, N.I., Tsarfaty, I. Nephrol. Dial. Transplant. (2003) [Pubmed]
  6. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Peschard, P., Fournier, T.M., Lamorte, L., Naujokas, M.A., Band, H., Langdon, W.Y., Park, M. Mol. Cell (2001) [Pubmed]
  7. Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met. Tomita, K., Azuma, T., Kitamura, N., Nishida, J., Tamiya, G., Oka, A., Inokuchi, S., Nishimura, T., Suematsu, M., Ishii, H. Gastroenterology (2004) [Pubmed]
  8. c-Met responsiveness of isolated hepatocytes evaluated in an in vitro de-differentiation model. Boost, K.A., Kim, H.J., Engl, T., Oppermann, E., Jonas, D., Oertl, A., Blaheta, R.A. Int. J. Mol. Med. (2006) [Pubmed]
  9. Hepatocyte growth factor stimulates DNA synthesis in rat preneoplastic hepatocytes but not in liver carcinoma cells. Ogasawara, H., Hiramoto, J., Takahashi, M., Shirahama, K., Furusaka, A., Hiyane, S., Nakada, T., Nagayama, K., Tanaka, T. Gastroenterology (1998) [Pubmed]
  10. Hepatocyte growth factor (HGF/SF) is a muscle-derived survival factor for a subpopulation of embryonic motoneurons. Yamamoto, Y., Livet, J., Pollock, R.A., Garces, A., Arce, V., deLapeyrière, O., Henderson, C.E. Development (1997) [Pubmed]
  11. Hepatocyte growth factor receptor in acute tubular necrosis. Rabkin, R., Fervenza, F., Tsao, T., Sibley, R., Friedlaender, M., Hsu, F., Lassman, C., Hausmann, M., Huie, P., Schwall, R.H. J. Am. Soc. Nephrol. (2001) [Pubmed]
  12. Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma. Humphrey, P.A., Zhu, X., Zarnegar, R., Swanson, P.E., Ratliff, T.L., Vollmer, R.T., Day, M.L. Am. J. Pathol. (1995) [Pubmed]
  13. Hepatocyte growth factor as an enhancer of nmda currents and synaptic plasticity in the hippocampus. Akimoto, M., Baba, A., Ikeda-Matsuo, Y., Yamada, M.K., Itamura, R., Nishiyama, N., Ikegaya, Y., Matsuki, N. Neuroscience (2004) [Pubmed]
  14. Modulation of estrogen production and 17beta-hydroxysteroid dehydrogenase-type 1, cytochrome P450 aromatase, c-met, and protein kinase Balpha messenger ribonucleic acid content in rat ovarian granulosa cells by hepatocyte growth factor and follicle-stimulating hormone. Zachow, R.J., Ramski, B.E., Lee, H. Biol. Reprod. (2000) [Pubmed]
  15. Ameliorative effect of hepatocyte growth factor on glycerol-induced acute renal failure with acute tubular necrosis. Nagano, T., Mori-Kudo, I., Tsuchida, A., Kawamura, T., Taiji, M., Noguchi, H. Nephron (2002) [Pubmed]
  16. Primary structure of rat HGF receptor and induced expression in glomerular mesangial cells. Liu, Y., Tolbert, E.M., Sun, A.M., Dworkin, L.D. Am. J. Physiol. (1996) [Pubmed]
  17. Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation. Baatar, D., Jones, M.K., Pai, R., Kawanaka, H., Szabo, I.L., Moon, W.S., Kitano, S., Tarnawski, A.S. Am. J. Pathol. (2002) [Pubmed]
  18. Heparin modulates the receptor-binding and mitogenic activity of hepatocyte growth factor on hepatocytes. Naka, D., Ishii, T., Shimomura, T., Hishida, T., Hara, H. Exp. Cell Res. (1993) [Pubmed]
  19. Hepatocyte growth factor/scatter factor modulates cell motility, proliferation, and proteoglycan synthesis of chondrocytes. Takebayashi, T., Iwamoto, M., Jikko, A., Matsumura, T., Enomoto-Iwamoto, M., Myoukai, F., Koyama, E., Yamaai, T., Matsumoto, K., Nakamura, T. J. Cell Biol. (1995) [Pubmed]
  20. Phenobarbital suppresses growth and accelerates restoration of differentiation markers of primary culture rat hepatocytes in the chemically defined hepatocyte growth medium containing hepatocyte growth factor and epidermal growth factor. Miyazaki, M., Mars, W.M., Runge, D., Kim, T.H., Bowen, W.C., Michalopoulos, G.K. Exp. Cell Res. (1998) [Pubmed]
  21. Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus. Fixman, E.D., Naujokas, M.A., Rodrigues, G.A., Moran, M.F., Park, M. Oncogene (1995) [Pubmed]
  22. Differential distribution of Met and epidermal growth factor receptor in normal and carcinogen-treated rat liver. Huitfeldt, H.S., Skarpen, E., Lindeman, B., Becher, R., Thrane, E.V., Schwarze, P.E. J. Histochem. Cytochem. (1996) [Pubmed]
  23. Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat. Stolz, D.B., Mars, W.M., Petersen, B.E., Kim, T.H., Michalopoulos, G.K. Cancer Res. (1999) [Pubmed]
  24. Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA. Wallenius, V.R., Rawet, H., Skrtic, S., Helou, K., Qiu, Y., Levan, G., Ekberg, S., Carlsson, B., Isaksson, O.G., Nakamura, T., Jansson, J.O. Mamm. Genome (1997) [Pubmed]
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