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Gene Review

col2a1a  -  collagen type II, alpha-1a

Danio rerio

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High impact information on col2a1a

  • Expression of sox9a/b correlates well with that of col2a1 in chondrogenic elements [1].
  • The expression profile of chm1 was determined during zebrafish embryonic development and compared to that of type II collagen (col2a1) [2].
  • Surprisingly, no hsp47 mRNA is detectable in the strongly col2a1-expressing cells of the floor plate and hypochord, indicating that the two genes are not strictly co-regulated [3].
  • Strong expression of hsp47 mRNA is co-incident predominantly with expression of the type II collagen gene (col2a1) in a number of chondrogenic and non-chondrogenic tissues including the notochord, otic vesicle and developing fins [3].
  • Because col2a1 expression reveals abnormalities in the notochord of cyclopsb16 embryos, and less col2a1-expressing mesenchyme accumulates rostral to the notochord in cyclops embryos, the effects of the cyclopsb16 mutation are not confined to the central nervous system [4].

Biological context of col2a1a

  • Appearance of the larger transcript occurs following somitogenesis, a time which coincides with the co-activation of hsp47 and col2a1 gene expression in tissues outside of the notochord [3].

Anatomical context of col2a1a

  • Along the embryonic axis, col2a1 is expressed dynamically in three rows that are each a single cell wide: the notochord and the rows of cells immediately dorsal and ventral to it--the floor plate of the central nervous system, and the hypochord [4].
  • The results showed that the spatial and temporal pattern of col2a1 expression in axial mesoderm follows the expression of twist closer than other genes tested [4].
  • In addition, col2a1 is expressed in the pharyngeal arches, the epithelium of the otic capsule, and in the mesenchyme of the neurocranium [4].
  • In cyclops embryos, which lack an intact floor plate, col2a1 expression was usually low, but not missing in cells in the ventral spinal cord [4].

Analytical, diagnostic and therapeutic context of col2a1a

  • Finally, Northern blot analysis revealed two alternative transcripts of col2a1 which are expressed in distinct temporal patterns [3].


  1. Two sox9 genes on duplicated zebrafish chromosomes: expression of similar transcription activators in distinct sites. Chiang, E.F., Pai, C.I., Wyatt, M., Yan, Y.L., Postlethwait, J., Chung, B. Dev. Biol. (2001) [Pubmed]
  2. Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis. Sachdev, S.W., Dietz, U.H., Oshima, Y., Lang, M.R., Knapik, E.W., Hiraki, Y., Shukunami, C. Mech. Dev. (2001) [Pubmed]
  3. Expression of genes encoding the collagen-binding heat shock protein (Hsp47) and type II collagen in developing zebrafish embryos. Lele, Z., Krone, P.H. Mech. Dev. (1997) [Pubmed]
  4. Expression of a type II collagen gene in the zebrafish embryonic axis. Yan, Y.L., Hatta, K., Riggleman, B., Postlethwait, J.H. Dev. Dyn. (1995) [Pubmed]
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